The protective effect of Bifidobacterium breve K-110, K-111 and B. infantis K-525 on carbon tetrachloride-induced hepatotoxicity in Rats

摘要

The protective effect of Bifidobacterium breve K-110, K-111 and B. infantis K-525 on carbon tetrachlorideinduced hepatotoxicity in rats was investigated. Among them, B. infantis K-525 had the most potent hepatoprotective activity. It reduced serum aspartate aminotransferase and alanine aminotransferase levels to 51% and 80% of the CCl_4-treated groups, respectively. In rat liver homogenate intoxificated with CC1_4, B. infantis K-525 inhibited in vitro as well as in vivo lipid peroxidation more than the other Bifidobacteria.