Design, synthesis and evaluation of novel F-19 magnetic resonance sensitive protein tyrosine phosphatase inhibitors

摘要

Fluorine is a highly attractive element for both medicinal chemistry and imaging technologies. To facilitate protein tyrosine phosphatase (PTP)-targeted drug discovery and imaging-guided PTP research on fluorine, several highly potent and F-19 MR sensitive PTP inhibitors were discovered through a structure-based focused library strategy.