Modelling and docking studies on Seryl tRNA synthetase of Plasmodium falciparum 3D7 as a potential drug target

摘要

Aim. Multidrug resistant strain Plasmodium fakiparum 3D7 (Pf), is the main causative organism of cerebral malaria. One strategy to over come resistance involves the inhibition of essential enzymes from the metabolic network of P falciparum. Pf Seryl tRNA synthetase (Pf StRNAse) is an enzyme involved in the amino acylation of protein translation. Inhibition of this enzyme prevents amino acylation. This study includes an Insilco approach using modelling and docking of Pf StRNAse protein with available antimalarial drugs from the ZINC database for the prediction of potent drug.