Taste-masking techniques in pharmaceutical formulations have become an important issue to improve patient convenience.1 Some drugs have an innate bitter taste, leading to their rejection by patients. Therefore, many researchers have aimed to mask the bitter taste of various drugs including aspirin, ibu-profen, and acetaminophen. The general approaches for taste-masking include neutralizing with sweeteners, encapsulating with tablets or capsules, and surface coating of drugs using edible polymers. Sweeteners and tablets can achieve taste masking by neutralizing taste and delaying drug release, but they do not completely eliminate the bitter taste. Furthermore, children, adults, and mental patients have a problem with taking bitter drugs. As an alternative, much attention has been paid to the fabrication of granules or powders by coating drug particles using enteric polymers.
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