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Gallium-containing anticancer compounds

机译:含镓抗癌化合物

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There is an ever pressing need to develop new drugs for the treatment of cancer. Gallium nitrate, a group IIIa metal salt, inhibits the proliferation of tumor cells in vitro and in vivo and has shown activity against non-Hodgkins lymphoma and bladder cancer in clinical trials. Gallium can function as an iron mimetic and perturb iron-dependent proliferation and other iron-related processes in tumor cells. Gallium nitrate lacks crossresistance with conventional chemotherapeutic drugs and is not myelosuppressive; it can be used when other drugs have failed or when the blood count is low. Given the therapeutic potential of gallium, newer generations of gallium compounds are now in various phases of preclinical and clinical development. These compounds hold the promise of greater anti-tumor activity against a broader spectrum of cancers. The development of gallium compounds for cancer treatment and their mechanisms of action will be discussed.
机译:迫切需要开发用于治疗癌症的新药。硝酸镓(一种IIIa类金属盐)在体外和体内均抑制肿瘤细胞的增殖,并且在临床试验中显示出对非霍奇金淋巴瘤和膀胱癌的活性。镓可以起到模拟铁的作用,并干扰肿瘤细胞中铁依赖性的增殖和其他铁相关的过程。硝酸镓缺乏与常规化学治疗药物的交叉耐药性,并且没有骨髓抑制作用。当其他药物失败或血液计数低时,可以使用它。鉴于镓的治疗潜力,新一代镓化合物目前处于临床前和临床开发的各个阶段。这些化合物有望对更广泛的癌症具有更大的抗肿瘤活性。将讨论用于癌症治疗的镓化合物的开发及其作用机理。

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