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Future medicinal chemistry

SCIMEDLINECA

中文名称：未来的药物化学

ISSN：1756-8919
出版周期：Monthly

发文量：1030

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1.Development of small macrocyclic kinase inhibitors

机译：Development of small macrocyclic kinase inhibitors
- 作者：Ma Jin;Sanchez-Duffhues Gonzalo;Caradec JosselinBenderitter PascalHoflack Janten Dijke Peter
- 期刊名称：《Future medicinal chemistry》 | 2022年第6期
- angiogenesis;
- fibrodysplasia ossificans progressiva;
- kinase inhibitor;
- macrocycle;
- oncology;
2.Application of iron oxide nanoparticles to control the release of minocycline for the treatment of glioblastoma

机译：Application of iron oxide nanoparticles to control the release of minocycline for the treatment of glioblastoma
- 作者：Marco A Arriaga;Dean Michael Enriquez;Arely D SalinasRomeo Garcia Jr.Carlos Trevino De LeoSilverio A LopezKaren S MartirosyanSue Anne Chew
- 期刊名称：《Future medicinal chemistry》 | 2021年第21期
- drug delivery;
- hyperthermia;
- iron oxide nanoparticles;
- minocycline;
- PLGA scaffolds;
3.Synthesis and characterization of potent RIPK3 inhibitors based on a tricyclic scaffold

机译：Synthesis and characterization of potent RIPK3 inhibitors based on a tricyclic scaffold
- 作者：Wu Shuwei;Yang Qing;Ji YutingTian ShengMa HaikuoDu ShujingLu HaohaoHe SudanZhang Xiaohu
- 期刊名称：《Future medicinal chemistry》 | 2022年第6期
- cell death;
- inflammation;
- necroptosis;
- RIPK3;
- structure-activity relationship;
- MIXED LINEAGE KINASE;
- DOMAIN-LIKE PROTEIN;
- CELL-DEATH;
- NECROPTOSIS;
- NECROSIS;
- INFLAMMATION;
- IDENTIFICATION;
- DOWNSTREAM;
4.Targeting mucin hypersecretion in COVID-19 therapy

机译：Targeting mucin hypersecretion in COVID-19 therapy
- 作者：Prasher Parteek;Sharma Mousmee
- 期刊名称：《Future medicinal chemistry》 | 2022年第10期
- COVID-19;
- mucins;
- SARS-CoV-2;
5.Proteolysis-targeting chimeras: a kaleidoscope of targeted protein degradation

机译：Proteolysis-targeting chimeras: a kaleidoscope of targeted protein degradation
- 作者：Mou Yi;Wen Shuai;Gao XinxingJiang Zheng-Yu
- 期刊名称：《Future medicinal chemistry》 | 2022年第3期
- E3 ligase;
- PROTAC;
- targeted protein degradation;
- UBIQUITINATION;
- DISCOVERY;
- KNOCKDOWN;
- TAU;
6.Discovery of novel and potent InhA inhibitors by an in silico screening and pharmacokinetic prediction

机译：Discovery of novel and potent InhA inhibitors by an in silico screening and pharmacokinetic prediction
- 作者：Hanwarinroj Chayanin;Phusi Nareudon;Kamsri BunditKamsri PharitPunkvang AuradeeKetrat SombatSaparpakorn PatchreenartHannongbua SupaSuttisintong KhomsonKittakoop PrasatSpencer JamesMulholland Adrian J.Pungpo Pornpan
- 期刊名称：《Future medicinal chemistry》 | 2022年第10期
- antibacterial prediction;
- glide docking;
- InhA inhibitor;
- MM-GBSA;
- MM-PBSA;
- Mycobacterium tuberculosis;
- virtual screening;
- WaterSwap;
- FORCE-FIELD;
- ACTIVITY SPECTRA;
- REDUCTASE;
- PROTEINS;
7.Rapid structure-based identification of potential SARS-CoV-2 main protease inhibitors

机译：Rapid structure-based identification of potential SARS-CoV-2 main protease inhibitors
- 作者：Sobhia M. Elizabeth;Kumar G. Siva;Sivangula SrikanthGhosh KetanSingh HarmanpreetHaokip ThongtinlalGibson Joseph
- 期刊名称：《Future medicinal chemistry》 | 2021年第17期
- SARS-CoV-2;
- main protease;
- water thermodynamics;
- structure based drug design;
- drug discovery;
8.Transition metal-catalyzed synthesis of new 3-substituted coumarin derivatives as antibacterial and cytostatic agents

机译：Transition metal-catalyzed synthesis of new 3-substituted coumarin derivatives as antibacterial and cytostatic agents
- 作者：Ivana Sokol;Mateja Toma;Mia KrnicAndrijana Mesck MacanDomagoj DrenjancevkSra LiekensSilvana Raic-MalicTatjana Gazivoda Kraljevk
- 期刊名称：《Future medicinal chemistry》 | 2021年第21期
9.The role of microRNA-21 in the onset and progression of cancer

机译：The role of microRNA-21 in the onset and progression of cancer
- 作者：Ashutosh Singh;Ashutosh Kumar Singh;Rajanish GiriDhruv KumarRohit SharmaMartin ValisKamil KucaNeha Garg
- 期刊名称：《Future medicinal chemistry》 | 2021年第21期
- apoptosis;
- cancer;
- cancer stem cells;
- carcinogenesis;
- metastasis;
- miR-21;
- miRNA;
10.Factorial design in the optimization and study 'in combo' of derivatives of imidazo1,2-aazines in the COX ' s isoforms inhibition

机译：Factorial design in the optimization and study 'in combo' of derivatives of imidazo1,2-aazines in the COX ' s isoforms inhibition
- 作者：Guerrero-Gonzalez Miguel;Campos Aldrete Maria-Elena;Antonio Meraz-Rios Marco
- 期刊名称：《Future medicinal chemistry》 | 2022年第11期
- COX inhibition;
- drug optimization;
- factorial design;
- imidazo1;
- 2-apyridine;
- 2-apyrimidine;
- CRYSTAL-STRUCTURES;
- CYCLOOXYGENASE;
- ACID;
11.Medicinal applications of coumarins bearing azetidinone and thiazolidinone moieties

机译：Medicinal applications of coumarins bearing azetidinone and thiazolidinone moieties
- 作者：Siddappa A Patil;Shivaputra A Patil;Temilade FariyikeKostiantyn O MarichevHector Mario Heras MartinezAlejro Bugarin
- 期刊名称：《Future medicinal chemistry》 | 2021年第21期
- anticancer;
- antimicrobial;
- antitubercular;
- antiviral;
- coumarin azetidinones;
- coumarin thiazolidinones;
12.PPAR gamma transcription effect on naturally occurring O-prenyl cinnamaldehydes and cinnamyl alcohol derivatives

机译：PPAR gamma transcription effect on naturally occurring O-prenyl cinnamaldehydes and cinnamyl alcohol derivatives
- 作者：Genovese Salvatore;Epifano Francesco;Rollinger Judith M.Fiorito Serena
- 期刊名称：《Future medicinal chemistry》 | 2021年第14期
- boropinal A;
- oxyprenylated secondary metabolites;
- pioglitazone;
- PPAR;
- 947;
- prenyloxycinnamaldehydes;
- prenyloxycinnamyl alcohols;
- Rutaceae;
13.Challenges and opportunities for in vivo PROTAC delivery

机译：Challenges and opportunities for in vivo PROTAC delivery
- 作者：Benowitz Andrew B.;Scott-Stevens Paul T.;Harling John D.
- 期刊名称：《Future medicinal chemistry》 | 2022年第3期
- chameleonicity;
- oral exposure;
- parenteral delivery;
- PROTAC;
14.Functional characterization of HIC, a P2Y1 agonist, as a p53 stabilizer for prostate cancer cell death induction

机译：Functional characterization of HIC, a P2Y1 agonist, as a p53 stabilizer for prostate cancer cell death induction
- 作者：Hien Thi Thu Le;Akshaya Murugesan;Nuno R CeiasOlli Yli-HarjaMeenakshisundaram Khavelu
- 期刊名称：《Future medicinal chemistry》 | 2021年第21期
- apoptosis;
- cell death;
- P2Y1 receptor;
- prostate cancer;
- signaling pathways;
15.The structural basis of effective LOX-1 inhibition

机译：The structural basis of effective LOX-1 inhibition
- 作者：Kore Rajshekhar A.;Bagchi Ashim K.;Varughese Kottayil IMehta Jawahar L.
- 期刊名称：《Future medicinal chemistry》 | 2022年第10期
16.TSPYL2 reduced gefitinib resistance and DNA damage repair via suppressing SIRT1-mediated FOXO3 deacetylation

机译：TSPYL2 reduced gefitinib resistance and DNA damage repair via suppressing SIRT1-mediated FOXO3 deacetylation
- 作者：Liu Zimeng;Li Chen;Yu ChangdaChen ZhibingZhao ChuanwenYe Lin
- 期刊名称：《Future medicinal chemistry》 | 2022年第6期
- colorectal cancer;
- FOXO3 deacetylation;
- gefitinib resistance;
- SIRT1;
- TSPYL2;
- COLORECTAL-CANCER;
17.Targeting STK33: from inhibition to degradation

机译：Targeting STK33: from inhibition to degradation
- 作者：Zhong Siying;Wayne Joanne
- 期刊名称：《Future medicinal chemistry》 | 2022年第3期
- KRAS synthetic lethality;
- STK33;
- targeted protein degradation;
- KRAS;
- KINASE;
18.EGFR-based dual inhibitors: current status and perspectives

机译：EGFR-based dual inhibitors: current status and perspectives
- 作者：He Huan;Qi Baohui
- 期刊名称：《Future medicinal chemistry》 | 2022年第9期
- anticancer;
- dual inhibitors;
- EGFR;
- non-small-cell lung cancers;
- GROWTH-FACTOR RECEPTOR;
- MUTATIONS;
19.Neurotensins and their therapeutic potential: research field study (vol 12, pg 1779, 2020)

机译：Neurotensins and their therapeutic potential: research field study (vol 12, pg 1779, 2020)
- 作者：Yeung Andy Wai Kan;Georgieva Maya G.;Kirilov Kiril
- 期刊名称：《Future medicinal chemistry》 | 2021年第17期
20.Identification of known drugs as potential SARS-CoV-2 Mpro inhibitors using ligand- and structure-based virtual screening

机译：Identification of known drugs as potential SARS-CoV-2 Mpro inhibitors using ligand- and structure-based virtual screening
- 作者：Federico Leonardo Bruno;Silva Guilherme Martins;da Silva Hage-Melim Lorane IzabelGomes Suzane QuintanaBarcelos Mariana PegrucciGalindo Francischini Isaque AntonioTomich de Paula da Silva Carlos Henrique
- 期刊名称：《Future medicinal chemistry》 | 2021年第16期
- COVID-19;
- drug repositioning;
- ligand-based drug discovery;
- main-protease (Mpro);
- SARS-CoV-2;
- structure-based drug discovery;
21.Synthesis of ponatinib analogues as novel inhibitors of leukemia stem cells

机译：Synthesis of ponatinib analogues as novel inhibitors of leukemia stem cells
- 作者：Wang Lei;Zhao Xiu-Juan;Hua ChuangWu Hai-XiangBai Cui-GaiChen Yue
- 期刊名称：《Future medicinal chemistry》 | 2022年第9期
- 1;
- 2;
- 3-triazole;
- 3;
- 4-oxadiazole;
- cell wound scratch assay;
- leukemia cells;
- plate cloning test;
- ponatinib analogues;
- trifluoromethyl;
- KINASE INHIBITOR;
- ABL;
- DISCOVERY;
- MUTATIONS;
- IMATINIB;
- MUTANT;
- POTENT;
22.Development and in vivo evaluation of fused benzazole analogs of anti-melanoma agent HA15

机译：Development and in vivo evaluation of fused benzazole analogs of anti-melanoma agent HA15
- 作者：Millet Antoine;Filho Mauro Safir;Hamouda-Tekaya NedraCavazza ElisaAbbe PatriciaRudiger JohannaPlaisant MagaliMayen JulieRocchi StephaneRonco CyrilBenhida Rachid
- 期刊名称：《Future medicinal chemistry》 | 2021年第14期
- anti-melanoma agent;
- antineoplastic activity;
- benzazole derivatives;
- HA15;
- mice xenografts;
23.Novel N-bridged pyrazole-1-carbothioamides with potential antiproliferative activity: design, synthesis, in vitro and in silico studies

机译：Novel N-bridged pyrazole-1-carbothioamides with potential antiproliferative activity: design, synthesis, in vitro and in silico studies
- 作者：Islam H El Azab;Essa M Saied;Alaa A OsmanAmir E MehanaHosam A SaadNadia AA Elkanzi
- 期刊名称：《Future medicinal chemistry》 | 2021年第20期
- 1;
- 2;
- 4-triazole;
- anticancer activity;
- apoptosis;
- CDK2;
- molecular docking;
- N-bridged heterocycles;
- pyrazole-1-phenylthiazoles;
- SK1;
24.Repurposing dyphylline as a pan-coronavirus antiviral therapy

机译：Repurposing dyphylline as a pan-coronavirus antiviral therapy
- 作者：Wang Yining;Rajpoot Sajjan;Li PengfeiLavrijsen MarlaMa ZhongrenHirani NikSaqib UzmaPan QiuweiBaig Mirza S.
- 期刊名称：《Future medicinal chemistry》 | 2022年第10期
- drug discovery;
- dyphylline;
- human coronaviruses (HCoVs);
- Mpro;
- repurposing;
- MAIN PROTEASE;
- SARS-COV-2;
- COVID-19;
- INHIBITORS;
- 3CL(PRO);
- INSIGHTS;
- DOCKING;
- DESIGN;
- DRUGS;
25.KSHV-specific antivirals targeting the protein-DNA interaction of the latency-associated nuclear antigen

机译：KSHV-specific antivirals targeting the protein-DNA interaction of the latency-associated nuclear antigen
- 作者：Berwanger Aylin;Empting Martin
- 期刊名称：《Future medicinal chemistry》 | 2021年第13期
- antiherpesviral agents;
- KSHV;
- LANA;
- latent infection;
- protein-DNA interactions;
- viral persistence;
26.A short overview of resistance to approved histone deacetylase inhibitors

机译：A short overview of resistance to approved histone deacetylase inhibitors
- 作者：Fischer Fabian;Alves Avelar Leandro A.
- 期刊名称：《Future medicinal chemistry》 | 2021年第14期
- cancer resistance;
- cancer therapy;
- epigenetics;
- histone deacetylases;
27.Design, synthesis and cytotoxic evaluation of peptoid analogs of an anticancer active triazolylpeptidyl penicillin

机译：Design, synthesis and cytotoxic evaluation of peptoid analogs of an anticancer active triazolylpeptidyl penicillin
- 作者：Martiren Nadia L.;Bellizzi Yanina;Barrionuevo ElizabethBlank Viviana C.Roguin Leonor P.Mata Ernesto G.Cornier Patricia G.
- 期刊名称：《Future medicinal chemistry》 | 2021年第13期
- antitumor;
- cancer;
- peptoid;
- solid-phase synthesis;
28.Engineering 'Enzymelink' for screening lead compounds to inhibit mPGES-1 while maintaining prostacyclin synthase activity

机译：Engineering 'Enzymelink' for screening lead compounds to inhibit mPGES-1 while maintaining prostacyclin synthase activity
- 作者：Ruan Diana T.;Tang Nanhong;Akasaka HironoriLu RenzhongRuan Ke-He
- 期刊名称：《Future medicinal chemistry》 | 2021年第13期
- COX-2;
- cyclooxygenase-2;
- Enzymelink;
- inhibitors;
- microsomal prostaglandin E-2 synthase-1;
- mPGES-1;
- PGIS;
- prostacyclin synthase;
29.Citrate transporter inhibitors: possible new anticancer agents

机译：Citrate transporter inhibitors: possible new anticancer agents
- 作者：Patil Shivaputra A.;Mayor June A.;Kaplan Ronald S.
- 期刊名称：《Future medicinal chemistry》 | 2022年第9期
30.Development and investigation of thiazolidinedione and pyrazoline compounds as antiangiogenic weapons targeting VEGFR-2

机译：Development and investigation of thiazolidinedione and pyrazoline compounds as antiangiogenic weapons targeting VEGFR-2
- 作者：Neha Upadhyay;Kalpana Tilekar;Sabreena SafuanAlan P KumarMarkus SchweipertFranz-Josef Meyer-AlmesCS Ramaa
- 期刊名称：《Future medicinal chemistry》 | 2021年第22期
- antiangiogenic;
- diaryl-pyrazoline;
- thiazolidinedione;
- VEGFR-2;
31.Combining EGFR inhibitors with SHP2 or LSD1 inhibitors to overcome multidrug resistance in cancer

机译：Combining EGFR inhibitors with SHP2 or LSD1 inhibitors to overcome multidrug resistance in cancer
- 作者：Zhang Huiqing;Yang Xinyu;Song YihuiYu Bin
- 期刊名称：《Future medicinal chemistry》 | 2022年第8期
- combination therapy;
- EGFR;
- LSD1;
- multidrug resistance;
- SHP2;
32.Thio-substituted derivatives of 4-amino-pyrazolo3,4-dpyrimidine-6-thiol as antiproliferative agents

机译：Thio-substituted derivatives of 4-amino-pyrazolo3,4-dpyrimidine-6-thiol as antiproliferative agents
- 作者：Cacciari Barbara;Romagnoli Romeo;Romani AriannaTrentini AlessandroHanau Stefania
- 期刊名称：《Future medicinal chemistry》 | 2021年第18期
- 4-amino-1-H-pyrazolo3;
- 4-dpyrimidine-6-thiol;
- antiproliferative activity;
- apoptosis;
- cancer;
- cell cycle;
- pyrazolo pyrimidine;
- U937;
33.Physicochemical and functional characterization of trastuzumab-dkst, a trastuzumab biosimilar

机译：Physicochemical and functional characterization of trastuzumab-dkst, a trastuzumab biosimilar
- 作者：Goyal Parag;Iyer Jyoti;Adhikary LaxmiVats BhaveshKabadi PradeepPai HarishRanayhossaini DanielGouda ShankaraSubbarao MaliniMehta GauravSaha ArindamBera ArnabSahu AbhilashiKaur ManinderSingh AnkitaMarwah AshwaniReddy Moole Praveen KumarSmith JeffreyMelarkode RamakrishnanUllanat Rajesh
- 期刊名称：《Future medicinal chemistry》 | 2021年第18期
- bioequivalence;
- breast cancer;
- cancer;
- trastuzumab;
- trastuzumab-dkst;
34.Sulfonamide-salicylaldehyde imines active against methicillin- and trimethoprim/sulfonamide-resistant Staphylococci

机译：Sulfonamide-salicylaldehyde imines active against methicillin- and trimethoprim/sulfonamide-resistant Staphylococci
- 作者：Martin Kratky;Klara Konecna;Jiri JanousekOndrej JourekJana MaixnerovaSara KalivodovaFrantisek TrejtnarJarmila Vinsova
- 期刊名称：《Future medicinal chemistry》 | 2021年第22期
- antibacterial activity;
- cytotoxicity;
- drug resistance;
- imine;
- in vitro activity;
- Schiff bases;
- Staphylococcus aureus;
- sulfamethoxazole;
- sulfonamides;
35.Synovial mesenchymal stem cell-derived exosomal miR-320c enhances chondrogenesis by targeting ADAM19

机译：Synovial mesenchymal stem cell-derived exosomal miR-320c enhances chondrogenesis by targeting ADAM19
- 作者：Kong Ruina;Gao Jie;Zhang JuJi LianmeiYu YiyiZhang LanlingZhao Dongbao
- 期刊名称：《Future medicinal chemistry》 | 2022年第2期
- chondrogenesis;
- exosomes;
- microRNA-320c;
- osteoarthritis;
- synovial mesenchymal stem cells;
- OSTEOARTHRITIS;
- PROLIFERATION;
- CHONDROCYTES;
- REGENERATION;
36.Structure-based molecular insights into matrix metalloproteinase inhibitors in cancer treatments

机译：Structure-based molecular insights into matrix metalloproteinase inhibitors in cancer treatments
- 作者：Lin Haili;Xu Peng;Huang Mingdong
- 期刊名称：《Future medicinal chemistry》 | 2022年第1期
37.Synthesis and activity of miconazole derivatives as dual BChE/IDO1 inhibitors for the treatment of Alzheimer's disease

机译：Synthesis and activity of miconazole derivatives as dual BChE/IDO1 inhibitors for the treatment of Alzheimer's disease
- 作者：Lu Xin;Liu Yijun;Qin NanYang HongyuQiao YutingJiang XueyangChen YaoFeng FengLiu WenyuanZhou YouSun Haopeng
- 期刊名称：《Future medicinal chemistry》 | 2021年第13期
- Alzheimerapos;
- s disease;
- cholinesterase inhibitors;
- IDO1;
38.P2Y14R for inflammation therapy: is it a promising target?

机译：P2Y14R for inflammation therapy: is it a promising target?
- 作者：Wang Yuyang;Duan Yongtao
- 期刊名称：《Future medicinal chemistry》 | 2021年第18期
- antagonists;
- inflammation;
- nucleotide;
- UDP;
39.A new class of 5-HT1A receptor antagonists with procognitive and antidepressant properties

机译：A new class of 5-HT1A receptor antagonists with procognitive and antidepressant properties
- 作者：Jankowska Agnieszka;Satala Grzegorz;Swierczek ArturPociecha KrzysztofPartyka AnnaJastrzebska-Wiesek MagdalenaGluch-Lutwin MonikaBojarski Andrzej J.Wyska ElzbietaChlon-Rzepa Grazyna
- 期刊名称：《Future medicinal chemistry》 | 2021年第18期
40.Advances of biphenyl small-molecule inhibitors targeting PD-1/PD-L1 interaction in cancer immunotherapy

机译：Advances of biphenyl small-molecule inhibitors targeting PD-1/PD-L1 interaction in cancer immunotherapy
- 作者：Chen Roufen;Yuan Dandan;Ma JunJie
- 期刊名称：《Future medicinal chemistry》 | 2022年第2期
- biphenyls;
- cancer immunotherapy;
- inhibitors;
- PD-1;
- PD-L1 interaction;
- small-molecule;
- T-CELLS;
- EXPRESSION;
- DERIVATIVES;
- BLOCKADE;
- TUMOR;
- DISCOVERY;
- PROTEIN;
- DESIGN;
- MEMBER;
41.Perspectives on the development of first-in-class protein degraders

机译：Perspectives on the development of first-in-class protein degraders
- 作者：Rambacher Kalyn M.;Calabrese Matthew F.;Yamaguchi Masaya
- 期刊名称：《Future medicinal chemistry》 | 2021年第14期
- autophagy;
- lysosome targeting;
- degrader toolbox;
- drug discovery;
- targeted protein degradation;
- ubiquitin proteasome system;
42.Novel carbonic anhydrase inhibitors

机译：Novel carbonic anhydrase inhibitors
- 作者：Claudiu T Supuran
- 期刊名称：《Future medicinal chemistry》 | 2021年第22期
- carbonic anhydrases;
- hypoxic tumors;
- inhibition mechanisms;
- inhibitors;
- pharmacological applications;
43.Latest progress in the development of cyclooxygenase-2 pathway inhibitors targeting microsomal prostaglandin E-2 synthase-1

机译：Latest progress in the development of cyclooxygenase-2 pathway inhibitors targeting microsomal prostaglandin E-2 synthase-1
- 作者：LaBorde Krista;Lu Renzhong;Ruan Ke-He
- 期刊名称：《Future medicinal chemistry》 | 2022年第6期
- anti-inflammation;
- COX-2 inhibitor;
- inhibitor;
- microsomal prostaglandin E-2 synthase-1;
- mPGES-1;
- PGE(2);
44.Bacterial carbonic anhydrases: underexploited antibacterial therapeutic targets

机译：Bacterial carbonic anhydrases: underexploited antibacterial therapeutic targets
- 作者：Daniel P Flaherty;Mohamed N Seleem;Claudiu T Supuran
- 期刊名称：《Future medicinal chemistry》 | 2021年第19期
- antibiotic drug discovery;
- bacterial carbonic anhydrase;
- carbonic anhydrase inhibitors;
45.Ligand-based design of anticancer MMP2 inhibitors: a review

机译：Ligand-based design of anticancer MMP2 inhibitors: a review
- 作者：Saptarshi Sanyal;Sk Abdul Amin;Nilanjan AdhikariTarun Jha
- 期刊名称：《Future medicinal chemistry》 | 2021年第22期
- cancer;
- ligand based drug design;
- MMP2;
- multi-QSAR;
- QSAR;
46.Design of SARS-CoV-2 Mpro, PLpro dual-target inhibitors based on deep reinforcement learning and virtual screening

机译：Design of SARS-CoV-2 Mpro, PLpro dual-target inhibitors based on deep reinforcement learning and virtual screening
- 作者：Zhang Li-chuan;Zhao Hui-lin;Liu JinHe LeiYu Ri-leiKang Cong-min
- 期刊名称：《Future medicinal chemistry》 | 2022年第6期
- covalent docking;
- deep reinforcement learning;
- drug design;
- molecular dynamics simulation;
- Mpro;
- PLpro;
- SARS-CORONAVIRUS;
- COVALENT INHIBITORS;
- DRUG DISCOVERY;
47.Novel inhibitors of the renal inward rectifier potassium channel of the mosquito vector Aedes aegypti

机译：Novel inhibitors of the renal inward rectifier potassium channel of the mosquito vector Aedes aegypti
- 作者：Viktoriya Mashinson;Corey R Hopkins
- 期刊名称：《Future medicinal chemistry》 | 2021年第22期
- ion channel;
- Kir channel;
- mosquitocide;
- mosquito vector;
- Zika virus;
48.Rifamycins: do not throw the baby out with the bathwater. Is rifampicin still an effective anti-tuberculosis drug?

机译：Rifamycins: do not throw the baby out with the bathwater. Is rifampicin still an effective anti-tuberculosis drug?
- 作者：Brucoli Federico;D McHugh Timothy
- 期刊名称：《Future medicinal chemistry》 | 2021年第24期
- antimicrobial resistance;
- first-line TB treatment;
- rifamycin;
- TB drug discovery;
- MYCOBACTERIUM-TUBERCULOSIS;
- REGIMENS;
49.Minimal screening requirements for identifying highly promiscuous kinase inhibitors

机译：Minimal screening requirements for identifying highly promiscuous kinase inhibitors
- 作者：Bajorath Juergen
- 期刊名称：《Future medicinal chemistry》 | 2021年第13期
- compound-based target relationships;
- computational analysis;
- human kinome;
- kinase inhibitors;
- multikinase activity;
50.Design and synthesis of novel aza-ursolic acid derivatives: in vitro cytotoxicity and nitric oxide release inhibitory activity

机译：Design and synthesis of novel aza-ursolic acid derivatives: in vitro cytotoxicity and nitric oxide release inhibitory activity
- 作者：Luan Mingzhu;Xu Yaoyao;Zhang XiaofanLi DaleiYan MengjunHou GuigeMeng QingguoZhao FengZhao Fenglan
- 期刊名称：《Future medicinal chemistry》 | 2022年第8期
- cytotoxicity;
- derivatives;
- in vitro anti-inflammatory activity;
- NO donor;
- synthesis;
- ursolic acid;
- ANTIINFLAMMATORY DRUGS;
- BIOLOGICAL EVALUATION;
- INFLAMMATION;
- DISEASES;
51.Quinazoline-based analog of adenine as an antidote against MLL-rearranged leukemia cells: synthesis, inhibition assays and docking studies

机译：Quinazoline-based analog of adenine as an antidote against MLL-rearranged leukemia cells: synthesis, inhibition assays and docking studies
- 作者：Bon Corentin;Barbachowska Magdalena;Djokovic NemanjaRuzic DusanSi YangSoresinetti LauraJallet CorinneTafit AmbreHalby LudovicNikolic KatarinaArimondo Paola B.
- 期刊名称：《Future medicinal chemistry》 | 2022年第8期
- adenine analogs;
- bisubstrate inhibitors;
- chemical probes;
- DOT1L;
- epigenetics;
- MLLr leukemia;
- DOT1L INHIBITORS;
- HISTONE METHYLATION;
- POTENT;
- EPIGENETICS;
- MECHANISMS;
- DISCOVERY;
- LANDSCAPE;
- EPZ-5676;
52.Recent advances of cannabidiol studies in medicinal chemistry, pharmacology and therapeutics

机译：Recent advances of cannabidiol studies in medicinal chemistry, pharmacology and therapeutics
- 作者：Karishma Thakkar;Cheng-Huai Ruan;Ke-He Ruan
- 期刊名称：《Future medicinal chemistry》 | 2021年第22期
- anti-inflammation;
- antioxidant;
- cannabidiol;
- cannabinoids;
- CBD;
- oxidative stress;
53.Welcome to Volume 14 of Future Medicinal Chemistry Foreword

机译：Welcome to Volume 14 of Future Medicinal Chemistry Foreword
- 作者：Wall Harriet
- 期刊名称：《Future medicinal chemistry》 | 2022年第1期
- drug design;
- Future Medicinal Chemistry;
- research;
- top content;
54.Synthesis of indole substituted thiosemicarbazones as an aldose reductase inhibitor: an in vitro, selectivity and in silico study

机译：Synthesis of indole substituted thiosemicarbazones as an aldose reductase inhibitor: an in vitro, selectivity and in silico study
- 作者：Shehzad Muhammad Tariq;Khan Ajmal;Halim Sobia AhsanHameed AbdulImran AqeelIqbal JamshedUllah AzizAsari AsnuzilawatiKhan SamraShafiq ZahidAl-Harrasi Ahmed
- 期刊名称：《Future medicinal chemistry》 | 2021年第14期
- aldehyde reductase;
- aldose reductase;
- antidiabetic agent;
- indole;
- sorbinil;
- thiosemicarbazone;
55.Cationic polysaccharides: emerging drug delivery vehicle across the physiological mucus barrier

机译：Cationic polysaccharides: emerging drug delivery vehicle across the physiological mucus barrier
- 作者：Prasher Parteek;Fatima Rabab;Sharma Mousmee
- 期刊名称：《Future medicinal chemistry》 | 2022年第8期
- biocompatible;
- biodegradable;
- cationic cellulose;
- cationic starch;
- chemical modification;
- chitosan;
- diaminated starch;
- drug delivery;
- mucoadhesive;
- mucus penetration;
56.Identification of a novel antifungal backbone of naphthalimide thiazoles with synergistic potential for chemical and dynamic treatment

机译：Identification of a novel antifungal backbone of naphthalimide thiazoles with synergistic potential for chemical and dynamic treatment
- 作者：Zhang Peng-Li;Lavanya Gopala;Yu YangFang BoZhou Cheng-He
- 期刊名称：《Future medicinal chemistry》 | 2021年第23期
- antifungal;
- naphthalimide;
- reactive oxidative species;
- thiazole;
- BIOLOGICAL EVALUATION;
- ANTIMICROBIAL EVALUATION;
- ANTIBACTERIAL AGENTS;
- BIOACTIVE EVALUATION;
- DNA;
- DESIGN;
- MEMBRANE;
- DERIVATIVES;
- RESISTANCE;
- DISCOVERY;
57.Targeted inhibition of the endonuclease activity of influenza polymerase acidic proteins

机译：Targeted inhibition of the endonuclease activity of influenza polymerase acidic proteins
- 作者：Ren Yixin;Chen Yongshou;Cao Shuang
- 期刊名称：《Future medicinal chemistry》 | 2022年第8期
- drug target;
- influenza viruses;
- PA inhibitors;
- polymerase acidic protein endonuclease inhibitors;
- research progress;
- RNA-POLYMERASE;
- BALOXAVIR MARBOXIL;
- CRYSTAL-STRUCTURE;
- CAP-BINDING;
- PA SUBUNIT;
- VIRUS;
- IDENTIFICATION;
- COMPLEX;
- DOMAIN;
- DRUG;
58.Molecular modeling studies of 4-(3H-benzoimidazol-5-yl)-pyrimidin-2-yl-amine-based CDK4 inhibitors

机译：Molecular modeling studies of 4-(3H-benzoimidazol-5-yl)-pyrimidin-2-yl-amine-based CDK4 inhibitors
- 作者：Lv Han;Du Yongli;Sheng XiehuangGao ZhipeiShen Jingkang
- 期刊名称：《Future medicinal chemistry》 | 2021年第16期
- abemaciclib;
- CDK4;
- CoMFA;
- CoMSIA;
- MD simulation;
- 3D-QSAR;
59.Diaminomaleonitrile derivatives as new potential antichagasic compounds: a study of structure-activity relationships

机译：Diaminomaleonitrile derivatives as new potential antichagasic compounds: a study of structure-activity relationships
- 作者：de Oliveira Aldo S.;Mello Lucas dos S.;Ogihara Camila H.Doring Thiago H.Palomino-Salcedo David L.Michelan-Duarte SimoneFerreira Leonardo L. G.Souza Julia M.Davila-Rodriguez Maria Joseda Cruz Junior Jose W.Dockal Edward R.Andricopulo Adriano D.
- 期刊名称：《Future medicinal chemistry》 | 2021年第24期
- Chagas disease;
- cruzain;
- diaminomaleonitrile;
- molecular docking;
- QSAR;
- SCHIFF-BASE COMPLEXES;
- RAY CRYSTAL-STRUCTURE;
- ANTIMICROBIAL ACTIVITIES;
- CYSTEINE PROTEASES;
- CHAGAS-DISEASE;
- CRUZAIN;
- INHIBITORS;
- CHEMISTRY;
- DOCKING;
- NICKEL(II);
60.Development and implementation of an enterprise-wide predictive model for early absorption, distribution, metabolism and excretion properties

机译：Development and implementation of an enterprise-wide predictive model for early absorption, distribution, metabolism and excretion properties
- 作者：Kiran Kumar;Vladimir Chupakhin;Ann VosDenise MorrisonDmitrii RassokhinMartin J DellwoKeith McCormickEric PaternosterHugo CeulemansRenee L DesJarlais
- 期刊名称：《Future medicinal chemistry》 | 2021年第19期
- ADME prediction;
- artificial intelligence;
- computer-aided drug design;
- drug discovery;
- machine learning;
- pharmaceutical chemistry;
61.A novel multi-target strategy to attenuate the progression of Parkinson's disease by diamine hybrid AGE/ALE inhibitor

机译：A novel multi-target strategy to attenuate the progression of Parkinson's disease by diamine hybrid AGE/ALE inhibitor
- 作者：Sasaki N. Andre;Sonnet Pascal
- 期刊名称：《Future medicinal chemistry》 | 2021年第24期
- AGE/ALE inhibitor;
- methylglyoxal;
- ortho-quinone;
- Parkinson's disease;
- quinoxaline;
- RCS;
- ROS;
- alpha-synuclein;
- ALPHA-SYNUCLEIN;
- RECEPTOR AGONISTS;
- DNA-ADDUCTS;
- DOPAMINE;
- GLYCATION;
- NEURODEGENERATION;
- AGGREGATION;
- ANTAGONISTS;
- TYROSINASE;
- TOXICITY;
62.2-hydroxy-1,4-naphthoquinones with 3-alkyldiarylether groups: synthesis and Plasmodium falciparum inhibitory activity

机译：2-hydroxy-1,4-naphthoquinones with 3-alkyldiarylether groups: synthesis and Plasmodium falciparum inhibitory activity
- 作者：Berg Amanda;Swartchick Chelsea B.;Forrest NoahChavarria MatthewDeem Madeleine C.Sillin Alyson N.Li YuexinRiscoe Teresa M.Nilsen AaronRiscoe Michael K.Wood Warren Jl
- 期刊名称：《Future medicinal chemistry》 | 2022年第22期
- 2-hydroxy-1;
- 4-naphthoquinones;
- malaria;
- Plasmodium falciparum;
- radical alkylation;
- three-component reductive alkylation;
- ANTIMALARIAL;
- 2-HYDROXY-3-ALKYL-1;
- 4-NAPHTHOQUINONES;
- THERAPEUTICS;
- DISCOVERY;
- DRUG;
63.Investigation of carbonic anhydrase inhibitory potency of (Z/E)-alkyl N‘-benzyl-N-(arylsulfonyl)-carbamimidothioates

机译：Investigation of carbonic anhydrase inhibitory potency of (Z/E)-alkyl N‘-benzyl-N-(arylsulfonyl)-carbamimidothioates
- 作者：Morteza Abdoli;Viviana De Luca;Clemente CapassoClaudiu T SupuranRaivis ?alubovskis
- 期刊名称：《Future medicinal chemistry》 | 2023年第7期
- antitumor;
- carbonic anhydrase;
- inhibitors;
- sulfonamides;
- (Z/E)-alkyl N'-benzyl-N-(arylsulfonyl)-carbamimidothioates;
64.New pyrrolopyridine-based thiazolotriazoles as diabetics inhibitors: enzymatic kinetics and in silico study

机译：New pyrrolopyridine-based thiazolotriazoles as diabetics inhibitors: enzymatic kinetics and in silico study
- 作者：Taha Muhammad;Rahim Fazal;Hayat ShawkatChigurupati SrideviKhand Khalid MohammedImran SyahrulAli Shah Syed AdnanUddin NizamFelemban Shatha GhaziVenugopal Vijayan
- 期刊名称：《Future medicinal chemistry》 | 2023年第5期
65.Recent advances in oxazolidinones as antituberculosis agents

机译：Recent advances in oxazolidinones as antituberculosis agents
- 作者：Lu H.;Wang H.;Zhao H.ZhangD.
- 期刊名称：《Future medicinal chemistry》 | 2022年第15期
- antituberculosis agents;
- mechanism of action;
- Mycobacterium tuberculosis;
- oxazolidinones;
- toxicity;
66.Potential strategies for the management of adenocarcinoma: a perspective

机译：Potential strategies for the management of adenocarcinoma: a perspective
- 作者：Parteek Prasher;Mousmee Sharma
- 期刊名称：《Future medicinal chemistry》 | 2023年第2期
67.Design, synthesis and antitumor activity of novel pyran-functionalized uracil derivatives: docking studies

机译：Design, synthesis and antitumor activity of novel pyran-functionalized uracil derivatives: docking studies
- 作者：Shehta Wael;Agili Fatimah;Farag BasantSaid Said A.Youssif ShakerAbdraboh Mohamed E.El-Kalyoubi Samar
- 期刊名称：《Future medicinal chemistry》 | 2023年第5期
- 5-(pyran-2-yl)uracil;
- 5-acetyl-6-aminouracil;
- 6-aminouracil;
- anticancer activity and molecular modeling;
- ONE-POT SYNTHESIS;
- FUSED URACILS;
- IN-VITRO;
- ANTIBACTERIAL;
- MECHANISMS;
- CATALYST;
- AGENTS;
68.Design and synthesis of selective FLT3 inhibitors via exploration of back pocket II

机译：Design and synthesis of selective FLT3 inhibitors via exploration of back pocket II
- 作者：Wang Qing-Xin;Cao Yu-Hao;Yang Li-JinMa Yi-YuanLi NanWu Shi-HanChen LuWu Jia-ZhenTong Zhen-JiangWang Xiao-LongXue XinDing NingLeng Xue-JiaoChang LiangDai Wei-ChenYu Yan-ChengSun Shan-LiangYang YeLi Nian-GuangShi Zhi-Hao
- 期刊名称：《Future medicinal chemistry》 | 2023年第1期
- acute myeloid leukemia;
- bioinformatics;
- FLT3;
- modeling;
- selectivity;
- small molecular inhibitors;
- structure-based;
- LEUKEMIA;
- RESISTANCE;
- DISCOVERY;
69.Novel pyrimido-pyridazine derivatives: design, synthesis, anticancer evaluation and in silico studies

机译：Novel pyrimido-pyridazine derivatives: design, synthesis, anticancer evaluation and in silico studies
- 作者：Sonker Priyanka;Singh Mamata;Nidhar ManishaSharma Vishal PrasadYadav PriyankaSingh RashmiKoch BiplobTewari Ashish Kumar
- 期刊名称：《Future medicinal chemistry》 | 2022年第23期
- in silico;
- in vitro;
- in vivo study;
- pyrimido-pyridazine derivatives;
- INHIBITORS;
- DISCOVERY;
- MOIETIES;
- AGENTS;
70.Virtual screening identifies tipranavir as a SIRT1 inhibitor with anti-hepatocarcinoma effect

机译：Virtual screening identifies tipranavir as a SIRT1 inhibitor with anti-hepatocarcinoma effect
- 作者：Shen Yan;Zhang Qingyu;Zhang LuWang JuanShu MaoHuang KuilongHu YongLin Zhihua
- 期刊名称：《Future medicinal chemistry》 | 2023年第5期
- hepatocellular carcinoma;
- SIRT1;
- tipranavir;
- virtual screening;
- HEPATOCELLULAR-CARCINOMA;
- DEACETYLATION;
- SELISISTAT;
- RESISTANCE;
- RITONAVIR;
- SIRTUINS;
- PROMOTES;
- CELLS;
- P53;
71.Gold: not just jewelry…

机译：Gold: not just jewelry…
- 作者：Federica Brescia;Luca Ronconi
- 期刊名称：《Future medicinal chemistry》 | 2023年第8期
72.Design, synthesis and evaluation of novel phenanthridine triazole analogs as potential antileishmanial agents

机译：Design, synthesis and evaluation of novel phenanthridine triazole analogs as potential antileishmanial agents
- 作者：Nandikolla Adinarayana;Singireddi Srinivasarao;Banoth Karan KumarMurugesan SankaranarayananAggarwal HimanshuBalana-Fouce RafaelEstela Melcon-FernandezChandra Sekhar Kondapalli Venkata Gowri
- 期刊名称：《Future medicinal chemistry》 | 2022年第12期
- in silico ADMET prediction;
- Leishmania infantum;
- molecular docking;
- phenanthridine;
- triazole;
- TRYPANOTHIONE REDUCTASE;
73.Hitting drug-resistant malaria infection with triazole-linked flavonoid-chloroquine hybrid compounds

机译：Hitting drug-resistant malaria infection with triazole-linked flavonoid-chloroquine hybrid compounds
- 作者：Seghetti Francesca;Belluti Federica;Rampa AngelaGobbi SilviaLegac JennyParapini SilviaBasilico NicolettaBisi Alessandra
- 期刊名称：《Future medicinal chemistry》 | 2022年第24期
- chloroquine hybrids;
- click chemistry;
- flavonoids;
- malaria prevention;
- malaria resistance;
- triazole linker;
- ANTIMALARIAL-DRUGS;
- SCAFFOLDS;
- CHALCONE;
- ANALOGS;
- DESIGN;
- POTENT;
- AGENTS;
74.Efficacy of natural antimicrobial peptides versus peptidomimetic analogues: a systematic review

机译：Efficacy of natural antimicrobial peptides versus peptidomimetic analogues: a systematic review
- 作者：Hellewell Lauren;Gilani Nakisa Malek;Stanton Christopher JamesPelligand LudovicFranzyk HenrikGuardabassi LucaGood Liam
- 期刊名称：《Future medicinal chemistry》 | 2022年第24期
75.Synthesis and molecular modeling studies of 1-benzyl-2-indolinones as selective AChE inhibitors

机译：Synthesis and molecular modeling studies of 1-benzyl-2-indolinones as selective AChE inhibitors
- 作者：Apaydin Cagla Begum;Soylu-Eter Ozge;Eraslan-Elma PinarOzsoy NurtenKarali Nilgun
- 期刊名称：《Future medicinal chemistry》 | 2022年第23期
76.Green solvent-free synthesis of new N-heterocycle-L-ascorbic acid hybrids and their antiproliferative evaluation

机译：Green solvent-free synthesis of new N-heterocycle-L-ascorbic acid hybrids and their antiproliferative evaluation
- 作者：Popov Andrea Bistrovic;Macan Andrijana Mescic;Jakopec SilvioPrpic HelenaHrkac Anja HarejPavelic Sandra KraljevicRaic-Malic Silvana
- 期刊名称：《Future medicinal chemistry》 | 2022年第16期
- 1;
- 2;
- 3-triazole;
- antitumor activity;
- CuAAC;
- green chemistry;
- L-ascorbic acid;
- mechanochemistry;
- nucleobase;
- purine;
- pyrimidine;
- AZIDE-ALKYNE CYCLOADDITION;
- CLICK CHEMISTRY;
- MEDICINAL MECHANOCHEMISTRY;
- VITAMIN-C;
- PYRIMIDINE;
- MECHANOSYNTHESIS;
- TECHNOLOGIES;
- DERIVATIVES;
- CELLS;
77.Human sirtuin 2 inhibitors, their mechanisms and binding modes

机译：Human sirtuin 2 inhibitors, their mechanisms and binding modes
- 作者：Penteado Andre Berndt;Hassanie Haifa;Gomes Renan AugustoEmery Flavio da SilvaTrossini Gustavo Henrique Goulart
- 期刊名称：《Future medicinal chemistry》 | 2023年第3期
78.Novel approaches for the treatment of infections due to multidrug-resistant bacterial pathogens

机译：Novel approaches for the treatment of infections due to multidrug-resistant bacterial pathogens
- 作者：Imran M.;Ahmad;M.N.Dasgupta A.Rana P.Srinivas N.ChopraS.
- 期刊名称：《Future medicinal chemistry》 | 2022年第15期
- AMR;
- antibacterial activity;
- bacteriophage therapy;
- drug discovery;
- host-directed therapy;
- immunomodulation;
- MDR;
- MRSA;
- natural products;
- novel antimicrobials;
- resistance mechanisms;
- VRE;
79.Identification of dual-targeted Mycobacterium tuberculosis aminoacyl-tRNA synthetase inhibitors using machine learning

机译：Identification of dual-targeted Mycobacterium tuberculosis aminoacyl-tRNA synthetase inhibitors using machine learning
- 作者：Galyna P Volynets;Mariia O Usenko;Olga I GudzeraSegiy A StarosylaAnatoliy O BalandaAnatolii R SyniuginOksana B GorbatiukAndrii O PrykhodkoVolodymyr G BdzholaSergiy M YarmolukMichael A Tukalo
- 期刊名称：《Future medicinal chemistry》 | 2022年第17期
80.Explainable machine learning for medicinal chemistry: exploring multi-target compounds

机译：Explainable machine learning for medicinal chemistry: exploring multi-target compounds
- 作者：Bajorath Juergen
- 期刊名称：《Future medicinal chemistry》 | 2022年第16期
81.Novel anthraquinone derivatives trigger endoplasmic reticulum stress response and induce apoptosis

机译：Novel anthraquinone derivatives trigger endoplasmic reticulum stress response and induce apoptosis
- 作者：Zhai Honglan;Wang Chunmiao;Li JunyingLiang DandanLi FengmingZhang QiupingWang JingniMa TuoLi DanrongHou Huaxin
- 期刊名称：《Future medicinal chemistry》 | 2023年第1期
- anthraquinone derivatives;
- anticancer;
- apoptosis;
- endoplasmic reticulum;
- UNFOLDED PROTEIN RESPONSE;
- CANCER CELLS;
- LUNG-CANCER;
- ER STRESS;
- AUTOPHAGY;
- INHIBITOR;
- ACTIVATION;
- EFFICACY;
- POTENT;
- DEATH;
82.Computational repurposing of benzimidazole anthelmintic drugs as potential colchicine binding site inhibitors

机译：Computational repurposing of benzimidazole anthelmintic drugs as potential colchicine binding site inhibitors
- 作者：Muhammad Khattab;Ahmed A Al-Karmalawy
- 期刊名称：《Future medicinal chemistry》 | 2021年第19期
- anthelmintics;
- CBSIs;
- drug repurposing;
- molecular docking;
- DFT calculations;
- tubulin inhibitors;
83.Combining virtual screening and in vitro evaluation for the discovery of potential CYP11B2 inhibitors

机译：Combining virtual screening and in vitro evaluation for the discovery of potential CYP11B2 inhibitors
- 作者：Li Jiali;Yu Na;Guo HongmeiShi YuanZeChen XiaoDieWu JinpingZhao XueminShu MaoWang RuiLin Zhihua
- 期刊名称：《Future medicinal chemistry》 | 2022年第17期
- biological activity;
- evaluation;
- inhibitor;
- virtual screening;
- ALDOSTERONE-SYNTHASE INHIBITION;
- AMBER;
- HYPERTENSION;
84.'Lights, squaraines, action!' - the role of squaraine dyes in photodynamic therapy

机译：'Lights, squaraines, action!' - the role of squaraine dyes in photodynamic therapy
- 作者：Lima Eurico;Reis Lucinda V
- 期刊名称：《Future medicinal chemistry》 | 2022年第19期
85.Investigation of halogenated furanones as inhibitors of quorum sensing-regulated bioluminescence in Vibrio harveyi

机译：Investigation of halogenated furanones as inhibitors of quorum sensing-regulated bioluminescence in Vibrio harveyi
- 作者：Pinheiro Jorge;Lyons Therese;Heras Vanessa LasRecio Miguel VilloriaGahan Cormac G. M.OSullivan Timothy P.
- 期刊名称：《Future medicinal chemistry》 | 2023年第4期
- bioluminescence;
- furanones;
- quorum sensing;
- Sonogashira;
- Suzuki;
- Vibrio harveyi;
- ALGA DELISEA-PULCHRA;
- BROMINATED FURANONES;
- BIOFILM FORMATION;
- LUMINOUS VIBRIOSIS;
- DRUG DISCOVERY;
- EXPRESSION;
- SYSTEMS;
- SHRIMP;
- LUXS;
- BACTERIA;
86.Protective effects of a novel glycogen phosphorylase inhibitor against cerebral ischemia–reperfusion injury in mice

机译：Protective effects of a novel glycogen phosphorylase inhibitor against cerebral ischemia–reperfusion injury in mice
- 作者：Zhiwei Yan;Shuai Li;Youde WangYachun GuoLiying Zhang
- 期刊名称：《Future medicinal chemistry》 | 2023年第7期
87.Recent advances in quinolone hybrids with potential antibacterial activity against drug-resistant bacteria

机译：Recent advances in quinolone hybrids with potential antibacterial activity against drug-resistant bacteria
- 作者：Wang Jun;Shi Yumin;Yan Heng
- 期刊名称：《Future medicinal chemistry》 | 2023年第6期
- antibacterial;
- drug resistance;
- fluoroquinolone;
- hybrid molecules;
- quinolone;
- structure–activity relationships;
88.Selected heterocycles for the development of pyrophosphate mimics

机译：Selected heterocycles for the development of pyrophosphate mimics
- 作者：Mousmee Sharma;Parteek Prasher
- 期刊名称：《Future medicinal chemistry》 | 2022年第17期
89.A systematic review of carbohydrate-based bioactive molecules for Alzheimer’s disease

机译：A systematic review of carbohydrate-based bioactive molecules for Alzheimer’s disease
- 作者：Nilesh Gajanan Bajad;Rayala Swetha;Gopich GuttiMeenakshi SinghAshok KumarSushil Kumar Singh
- 期刊名称：《Future medicinal chemistry》 | 2021年第19期
90.Tetrahydroquinoline: an efficient scaffold as mTOR inhibitor for the treatment of lung cancer

机译：Tetrahydroquinoline: an efficient scaffold as mTOR inhibitor for the treatment of lung cancer
- 作者：Chaube Udit;Dey Rajdeep;Shaw SumanPatel Bhumika D.Bhatt Hardik G.
- 期刊名称：《Future medicinal chemistry》 | 2022年第23期
91.The connection between PARP14 and SARS-CoV-2

机译：The connection between PARP14 and SARS-CoV-2
- 作者：Tauber Amanda L.;Schweiker Stephanie S.;Levonis Stephan M.
- 期刊名称：《Future medicinal chemistry》 | 2023年第3期
- ARTD8;
- coronavirus;
- COVID-19;
- immunity;
- PARP14;
- viral;
92.Management of adenocarcinoma with honokiol: progress so far and the way forward

机译：Management of adenocarcinoma with honokiol: progress so far and the way forward
- 作者：Parteek Prasher?;Mousmee Sharma?
- 期刊名称：《Future medicinal chemistry》 | 2023年第6期
93.5,7,3 ',4 '-tetramethoxyflavone ameliorates cholesterol dysregulation by mediating SIRT1/FOXO3a/ABCA1 signaling in osteoarthritis chondrocytes

机译：5,7,3 ',4 '-tetramethoxyflavone ameliorates cholesterol dysregulation by mediating SIRT1/FOXO3a/ABCA1 signaling in osteoarthritis chondrocytes
- 作者：Peng Fang;Huang Xianhua;Shi WeimeiXiao YaoshengJin QiLi LinfuXu DaohuaWu Longhuo
- 期刊名称：《Future medicinal chemistry》 | 2021年第24期
- ABCA1;
- FOXO3a;
- osteoarthritis;
- SIRT1;
- TMF;
- OXIDATIVE STRESS;
- BONE LOSS;
- EXPRESSION;
- PROTECTS;
- EFFLUX;
- FOXO3A;
- CELLS;
- INFLAMMATION;
- METABOLISM;
94.Thiosemicarbazones reprogram pancreatic cancer bidirectional oncogenic signaling between cancer cells and stellate cells to suppress desmoplasia

机译：Thiosemicarbazones reprogram pancreatic cancer bidirectional oncogenic signaling between cancer cells and stellate cells to suppress desmoplasia
- 作者：Richardson D. R.;Azad M. Gholam;Afroz R.Richardson VDharmasivam M.
- 期刊名称：《Future medicinal chemistry》 | 2022年第13期
95.Synthesis and in vitro study of pyrimidine–phthalimide hybrids as VEGFR2 inhibitors with antiproliferative activity

机译：Synthesis and in vitro study of pyrimidine–phthalimide hybrids as VEGFR2 inhibitors with antiproliferative activity
- 作者：Wael Shehta;Fatimah Agili;Basant FaragShaker YoussifSamar J AlmehmadiSherin M ElfekySamar El-Kalyoubi
- 期刊名称：《Future medicinal chemistry》 | 2023年第8期
- 4-amino-2;
- 6-dichloropyrimidine;
- ADME studies;
- antiproliferative activity;
- apoptosis;
- cell cycle arrest;
- enzyme inhibition;
- molecular docking;
- VEGFR2;
96.Synthetic benzofuran-linked chalcones with dual actions: a potential therapeutic approach to manage diabetes mellitus

机译：Synthetic benzofuran-linked chalcones with dual actions: a potential therapeutic approach to manage diabetes mellitus
- 作者：Ali Irfan;Rafique Rafaila;Khan Khalid MohammedChigurupati SrideviJi XingyueWadood AbdulSalar UzmaAlmahmoud Suliman A.Rehman Ashfaq UrFelemban Shatha GhaziHameed ShehryarPerveen Shahnaz
- 期刊名称：《Future medicinal chemistry》 | 2023年第1期
- benzofuran;
- chalcone;
- in silico;
- in vitro;
- radical scavenger;
- synthesis;
- alpha-amylase;
- DERIVATIVES;
- SCAFFOLD;
97.Piperazine-1,2,3-triazole scaffolds: design, synthesis, anticancer and antimicrobial evaluation

机译：Piperazine-1,2,3-triazole scaffolds: design, synthesis, anticancer and antimicrobial evaluation
- 作者：Priyanka Yadav;Chander Prakash Kaushik;Archna YadavJyoti YadavDharmendra Singh
- 期刊名称：《Future medicinal chemistry》 | 2023年第8期
- 1;
- 2;
- 3-triazole;
- anticancer activity;
- antimicrobial activity;
- click chemistry;
- piperazine;
98.Recent advancements in the discovery of cereblon-based protease-targeted chimeras with potential for therapeutic intervention

机译：Recent advancements in the discovery of cereblon-based protease-targeted chimeras with potential for therapeutic intervention
- 作者：Singh Harbinder;Agrawal Devendra K.
- 期刊名称：《Future medicinal chemistry》 | 2022年第19期
- cereblon;
- clinical progression;
- CRBN;
- E3 ligase;
- PROTAC;
- protein degradation;
- ubiquitination;
- E3 UBIQUITIN LIGASE;
- FUNCTIONAL-CHARACTERIZATION;
- SMALL MOLECULES;
- CELL BIOLOGY;
- DEGRADATION;
- GLUTAMINE;
- DESIGN;
- VHL;
- IDENTIFICATION;
- OPTIMIZATION;
99.Benzodthiazole-2-carboxamides as new antituberculosis chemotypes inhibiting mycobacterial ATP phosphoribosyl transferase

机译：Benzodthiazole-2-carboxamides as new antituberculosis chemotypes inhibiting mycobacterial ATP phosphoribosyl transferase
- 作者：Dhameliya Tejas M.;Tiwari Rishu;Banerjee ArkaprabhaPancholia SahajSriram DharmarajanPanda DulalChakraborti Asit K.
- 期刊名称：《Future medicinal chemistry》 | 2022年第24期
100.Structure modification: a successful tool for prodrug design

机译：Structure modification: a successful tool for prodrug design
- 作者：Cheng Yuexuan;Zhong Chunhong;Yan ShujingChen ChunliGao Xiaoli
- 期刊名称：《Future medicinal chemistry》 | 2023年第4期
- lipidic prodrugs;
- microenvironment responsive prodrugs;
- prodrug;
- structure modification;
- water-soluble prodrugs;
- INTESTINAL LYMPHATIC TRANSPORT;
- ACID CONJUGATE;
- DRUG-DELIVERY;
- PH;
- MECHANISMS;
- ROS;
- CAMPTOTHECIN;
- DIDANOSINE;
- STRATEGIES;
- DISCOVERY;

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