Preparation of Benzoyloxy Benzophenone Derivatives and Their InhibitoryEffects of ICAM-1 Expression

摘要

Benzoyloxy benzophenone derivatives were prepared in 3 steps including DCC coupling, Fries rearrangement and esterification from benzoic acids in 24-89% total yields. Among the prepared 12 benzophenone analogues 1a-11, the compound 1b having three chloro groups at the para position showed maximum inhibitory effects of ICAM-1 expression but, la which have no substituents at all showed no inhibitory activity. This study provides the evidences that benzoyloxy benzophenone derivative, 1b may exert its anti-inflammatory activity by suppressing IFN-γ-induced ICAM-1 expression.