Catalytic Enantioselective Diethylzinc Addition to N-Phosphinoylimine Using Thiophosphoramide of Homologated Binaphthyl N,O-Ligand

摘要

Catalytic enantioselective reactions that convert imines to alpha-chiral amines hold an important place in asymmetric synthesis,because these chiral amines are among the most common chiral subunits of biologically active molecules.The success of forming an alpha-chiral amine from an imine depends heavily on the electrophilicity of the imine and the nucleophilicity of the organometals,as well as on the amounts of chiral ligands.