The Catalytic Asymmetric Addition of Diethylzinc to N-(Diphenylphosphinoyl) Imines Catalyzed by Cu(OTf)_2-Chiral N-(Binaphthyl-2-yl) thiophosphoramide Ligands

摘要

Chiral N-(binaphthyl-2-yl) thiophosphor-amide L7 [O,O-dethyl 2'-(ethylamino)-1,1'-binaphth-yl-2-ylamidothiophosphate] prepared from the reaction of diethyl chlorothiophosphate with (R)-(+)-N-ethyl-1,1'-binaphthyl-2,2'-diamine was used as a catalytic chiral ligand in the first Cu(OTf)_2-promot-ed catalytic asymmetric addition of diethylzinc to N-(diphenylphosphinoyl) imines in which -85% ee can be realized.