Chemical Constituents of the Rhizome of Eleutherine bulbosa and Their Inhibitory Effect on the Pro-Inflammatory Cytokines Production in Lipopolysaccharide -Stimulated Bone Marrow-derived Dendritic Cells

摘要

Inflammatory responses, initiated by the invasion of pathogens or by tissue injury caused by free radicals, are a series of vascular and cellular reactions. Some important chemical mediators of inflammation are interleukin (IL)-l, -6, -12, and tumor necrosis factor-a, prostaglandins, etc... IL-6 has pro- and anti-inflammatory properties. IL-6 is involved not only in the activation of the immune system but also in regenerative process as well as in the regulation of metabolism. The IL-12 family of cytokines is key players in the regulation of T cell responses. IL-12 has both early proinflammatory and late anti-inflammatory effects. In addition to these, TNF-a is a well-characterized pro-inflammatory cytokine released primarily from monocytes and macrophages upon invasion of the host by a wide variety of pathogens. It plays a crucial role in host defense and in the inflammatory response. Although it has numerous beneficial roles in immune regulation, it has also been implicated in the pathogenesis of both acute and chronic inflammatory disease.