Triclosan produces statistically significant reduction in plaque, gingivitis and caries but not clinically important benefit

摘要

Question: Are triclosan/copoiymer containing fluoride toothpastes more effective than fluoride toothpastes for control of caries, plaque and gingivitis in children and adults? Data sources The Cochrane Oral Health Group's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase and the US National Institutes of Health Trials Register. Study selection Randomised controlled trials (RCTs) of parallel or crossover design, (with a sufficient wash-out period) of at least six months duration, and irrespective of language or publication status. Data extraction and synthesis Study assessment and data extraction were carried out independently by at least two reviewers. Meta-analysis was conducted using random-effects models when there were at least four studies (fixed-effect models when fewer than four studies), reporting mean differences (MD) for continuous data and risk ratios (RR) for dichotomous data.