Steroeselective synthesis of beta-amino ketones via direct Mannich-type reactions, catalyzed with ZrOCl2 center dot 8H(2)O under solvent-free conditions

摘要

At room temperature, zirconium oxychloride (ZrOCl2 center dot 8H(2)O) efficiently catalyzes the direct Mannich-type reaction of a variety of in situ generated aldimines using aldehydes and anilines with ketones in a three-component reaction under solvent-free conditions. The reaction proceeds rapidly and affords the corresponding beta-amino ketones in good to high yields with good to excellent stereoselectivities. The catalyst can be recycled for subsequent reactions without any appreciable loss of efficiency. (c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006.