Enantioselective Direct Mannich-Type Reactions of 2-Benzylpyridine N-Oxides Catalyzed by Chiral Bis(guanidino)iminophosphorane Organosuperbase

摘要

2-Substituted azaarenes with a stereogenic center at the α position are the common units existing in natural products and pharmaceuticals. Although several enantioselective methods to synthesize such azaarenes have been established, the strategy using direct α-deprotonation of 2-alkylazaarenes by chiral organobase catalysts is rarely reported.