Highly Efficient Synthesis of beta-Amino Ketones via Direct Mannich-type Reaction Catalyzed by Acidic Ionic Liquid

摘要

[MPSIm](+)CF(3)COO(-) ionic liquid is an efficient green catalyst for the one-pot, three-component Mannich-type reaction of aromatic aldehydes, aromatic amines and cyclohexanone. The reaction was completed within 5-60 min to give the corresponding beta-amino ketones in 82-98% yield at room temperature. The catalyst can be recycled at least four times without significant decrease in activity.