新型功能化Brφsted酸性离子液体1,4-二(4-磺酸基丁基)哌嗪硫酸氢盐磺酸的合成及其对酮醛交叉Aldol缩合反应的催化作用

摘要

以哌嗪和1,4-丁基磺酸内酯为原料合成了新型功能化Brφsted酸性离子液体——1,4-二(4-磺酸基丁基)哌嗪硫酸氢盐磺酸{[( HSO3-b)2pi]2+·2[HSO4]-)SO3H(Ⅱ)},其结构经1H NMR和IR表征.在无溶剂(或无水乙醇)条件下,以Ⅱ催化环己酮与取代苯甲醛的交叉Aldol缩合反应,成功地合成了十个α,α’-二(苯基亚甲基)环己酮类化合物(3a ～3j),收率77.5％～85.7％,其结构经1H NMR,13C NMR和IR表征,其中3e ～ 3i为新化合物.%A novel functionalized Brested acidic ionic liquid, l,4-bis(4-sulfobutyl)piperazinum-bis (hydrogen sulfte) { [ (HSO3-b)2pi]2+· 2[HSO4] -}SO3H( Ⅱ ) } , was prepared from piperazine and 1,4-butane sultone. The structure was characterized by 1H NMR and IR. Using Ⅱ as the catalyst, ten α,α'-bis(substituted benzylidene)cyclohexanones(3a ~3j) were synthesized by cross-Aldol condensation reaction of cyclohexanone with substituted-benzaldehyde in solvent-free or anhydrous etha-nol. The structures were characterized by 1H NMR, 13C NMR and IR. 3e ~3i were new compounds.