(S)-(2R, 3R, 11bR) -3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido 2,1-a isoquinoline-2- Synthetic method for the preparation of yl 2-amino-3-methylbutanoate di (4-methylbenzenesulfonate)

摘要

(S)-(2R, 3R, 11bR) -3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido [2,1-a] isoquinoline-2- Provided herein is a process for preparing yl 2-amino-3-methylbutanoate di (4-methylbenzenesulfonate) or a solvate, hydrate or polymorph thereof. In other embodiments, the methods include (S)-(2R, 3R, 11bR) -3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b of greater than 95% purity. Hexahydro-1H-pyrido [2,1-a] isoquinolin-2-yl 2-amino-3-methylbutanoate di (4-methylbenzenesulfonate) is provided.