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首页> 外文期刊>European journal of preventive cardiology >Level of physical activity associated with risk of cardiovascular diseases and mortality in patients with type-2 diabetes: Report from the Swedish National Diabetes Register
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Level of physical activity associated with risk of cardiovascular diseases and mortality in patients with type-2 diabetes: Report from the Swedish National Diabetes Register

机译：2型糖尿病患者的体育锻炼与心血管疾病风险和死亡率相关：瑞典国家糖尿病登记处的报告

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Aims: To estimate risks of coronary heart disease (CHD), cardiovascular disease (CVD), and total mortality with low or higher levels of physical activity (PA) assessed with questionnaire, in an observational study of patients with type-2 diabetes from the Swedish National Diabetes Register. Subjects and methods: A total of 15,462 patients (60 years), were followed for 5 years from baseline in 2004 until 2009, with 760 CVD events and 427 total mortality events based on 54,344 person-years. Results: Comparing 6963 patients with low baseline PA (never or 1-2 times/week for 30 min) and 8499 patients with higher baseline PA (regular 3 times/week or more), hazard ratios for fatalonfatal CHD, fatalonfatal CVD, fatal CVD, and total mortality were 1.25 (95% CI 1.05-1.48; p=0.01), 1.26 (95% CI 1.09-1.45; p=0.002), 1.69 (95% CI 1.18-2.41; p=0.004), and 1.48 (95% CI 1.22-1.79; p<0.001), adjusting for age, sex, diabetes duration, diabetes treatment, and smoking (model 1). Adjusting also for HbA1c, systolic blood pressure, low- and high-density lipoprotein cholesterol, triglycerides, body mass index, and albuminuria (model 2), HRs were 1.19 (95% CI 1.00-1.42; p=0.049), 1.18 (95% CI 1.02-1.36; p=0.04), 1.54 (95% CI 1.07-2.22; p=0.02), and 1.41 (95% CI 1.16-1.72; p<0.001), respectively. Corresponding results (model 2), comparing 4166 patients having low PA both baseline and at follow up with all other 11,296 patients were 1.68 (95% CI 1.41-2.01), 1.68 (95% CI 1.45-1.96), 2.12 (95% CI 1.48-3.03), and 2.03 (95% CI 1.66-2.48) (all p<0.001) and compared to 2797 patients with low baseline PA and higher PA at follow up were 2.51 (95% CI 1.87-3.38), 2.54 (95% CI 1.98-3.27), 3.26 (95% CI 1.74-6.10), and 2.91 (95% CI 2.08-4.07) (all p<0.001). Conclusions: This large observational study of patients with type-2 diabetes showed considerably increased risks for CVD and mortality with low PA.
机译：目的：在问卷调查中对2型糖尿病患者进行的一项观察性研究，评估通过问卷调查评估的冠心病（CHD），心血管疾病（CVD）和低总运动水平（PA）的总死亡率。瑞典国家糖尿病登记处。对象和方法：2004年至2009年，共对15462例患者（60岁）进行了为期5年的随访，共发生760例CVD事件和427例总死亡事件（基于54344人年）。结果：比较了6963名基线PA低的患者（30分钟内从未或每周1-2次，每周30分钟）和8499位基线PA高的患者（常规3次/周或更多），致命/非致命CHD，致命/非致命的危险比CVD，致命性CVD和总死亡率分别为1.25（95％CI 1.09-1.45; p = 0.01），1.26（95％CI 1.09-1.45; p = 0.002），1.69（95％CI 1.18-2.41; p = 0.004）和1.48（95％CI 1.22-1.79; p <0.001），针对年龄，性别，糖尿病持续时间，糖尿病治疗和吸烟进行了调整（模型1）。还针对HbA1c，收缩压，低密度脂蛋白胆固醇和高密度脂蛋白胆固醇，甘油三酸酯，体重指数和蛋白尿（模型2）进行了调整，HR为1.19（95％CI 1.00-1.42; p = 0.049），1.18（95 ％CI 1.02-1.36; p ＝ 0.04），1.54（95％CI 1.07-2.22; p ＝ 0.02）和1.41（95％CI 1.16-1.72; p ＜0.001）。相应的结果（模型2），将4166例基线和随访时均具有低PA的患者与其他所有11296例患者进行了比较，分别为1.68（95％CI 1.41-2.01），1.68（95％CI 1.45-1.96），2.12（95％CI 1.48-3.03）和2.03（95％CI 1.66-2.48）（全部p <0.001），与2797名随访时基线低PA和高PA的患者相比分别为2.51（95％CI 1.87-3.38），2.54（95 ％CI 1.98-3.27），3.26（95％CI 1.74-6.10）和2.91（95％CI 2.08-4.07）（全部p <0.001）。结论：这项对2型糖尿病患者的大型观察性研究表明，低PA患者发生CVD的风险和死亡率显着增加。

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