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首页> 外文期刊>European respiratory review >NONINVASIVE MARKERS OF AIRWAY INFLAMMATION AMD REDOX BIOCHEMISTRY APPLIED TO ASTHMA
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NONINVASIVE MARKERS OF AIRWAY INFLAMMATION AMD REDOX BIOCHEMISTRY APPLIED TO ASTHMA

机译:气道炎症的非侵入性标记AMD REDOX生物化学应用于哮喘

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At the European Respiratory Society (ERS) Annual Congress 2006.1 received the ERS Annual Award for Pediatric Respiratory Research in Europe for my research work on noninvasive markers of airway inflammation. Most of the studies in which I have been involved were conducted at the University of Padova. Padova. Italy. We have studied asthmatic children, and have demonstrated that some markers of inflammation (e.g cysteinyl leukotrienes) and oxidative stress (e.g. 8-isoprostane and malondialdehyde) are increased in their exhaled breath condensate, while antioxidant products, such as glutathione, are reduced. In addition, while I was working in the laboratory of Dr Benjamin Gaston at the University of Virginia. Charlottesville. VA USA. I conducted some basic research studies. A first group of experiments was aimed at investigating the role of rhinovirus infection in airway acidification. A second group of experiments was conducted to investigate the mechanisms involved in the regulation of expression S-nitrosoglutathione reductase (GSNOR), an enzyme that has a role in asthma pathogenesis, breaking down the endogenous bronchodilator GSNO.
机译:在欧洲呼吸学会(ERS)年度大会上,2006.1因我在气道炎症非侵入性标志物方面的研究工作而获得欧洲ERS儿科呼吸研究年度奖。我参与的大多数研究都是在帕多瓦大学进行的。帕多瓦。意大利。我们对哮喘儿童进行了研究,并证明了其呼出气冷凝物中某些炎症标志物(例如半胱氨酰白三烯)和氧化应激(例如8-异前列腺素和丙二醛)增加,而抗氧化剂产物(例如谷胱甘肽)减少了。另外,当我在弗吉尼亚大学的本杰明·加斯顿博士的实验室工作时。夏洛茨维尔。 VA美国。我进行了一些基础研究。第一组实验旨在研究鼻病毒感染在气道酸化中的作用。进行了第二组实验,以研究调节表达S-亚硝基谷胱甘肽还原酶(GSNOR)的机制,S-亚硝基谷胱甘肽还原酶是一种与哮喘发病有关的酶,可分解内源性支气管扩张剂GSNO。

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