Endogenous ligands of PPAR-gamma reduce the liver injury in haemorrhagic shock.

摘要

We demonstrate here for the first time that the novel, potent peroxisome proliferator-activated receptor (PPAR)-gamma antagonist GW9662 (2-chloro-5-nitrobenzanilide) augments the degree of liver injury associated with haemorrhagic (haemorrhage for 90 min and resuscitation for 4 h), but not endotoxic (6 mg/kg E. coli endotoxin i.v. for 6 h) shock in the anaesthetised rat. Thus, endogenous ligands for PPAR-gamma are released in haemorrhagic, but not endotoxic, shock in sufficient amounts to protect against injury.