Phase II randomised trial of autologous tumour lysate dendritic cell plus best supportive care compared with best supportive care in pre-treated advanced colorectal cancer patients

Caballero-Banos Miguel; Benitez-Ribas Daniel; Tabera Jaime; Varea Sara; Vilana Ramon; Bianchi Luis; Ramon Ayuso Juan; Pages Mario; Carrera Gemma; Cuatrecasas Miriam; Martin-Richard Marta; Cid Joan; Lozano Miguel; Castells Antoni; Garcia-Albeniz Xabier; Maurel Joan; Vilella Ramon

首页> 外文期刊>European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) >Phase II randomised trial of autologous tumour lysate dendritic cell plus best supportive care compared with best supportive care in pre-treated advanced colorectal cancer patients

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Phase II randomised trial of autologous tumour lysate dendritic cell plus best supportive care compared with best supportive care in pre-treated advanced colorectal cancer patients

机译：预治疗的晚期大肠癌患者自体肿瘤溶解产物树突状细胞加最佳支持治疗与最佳支持治疗的II期随机试验

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Background: Autologous tumour lysate dendritic cell vaccine (ADC) has T-cell stimulatory capacity and, therefore, potential antitumour activity. We designed a phase II randomised trial of ADC + best supportive care (BSC) (experimental arm [EA]) compared with BSC (control arm [CA]), in pre-treated metastatic colorectal cancer (mCRC) patients.

机译：背景：自体肿瘤溶解产物树突状细胞疫苗（ADC）具有T细胞刺激能力，因此具有潜在的抗肿瘤活性。我们设计了在治疗转移性结直肠癌（mCRC）患者中进行ADC +最佳支持治疗（BSC）（实验组[EA]）与BSC（对照组[CA]）的II期随机试验。

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《European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)》 |2016年第null期|共8页
作者
Caballero-Banos Miguel; Benitez-Ribas Daniel; Tabera Jaime; Varea Sara; Vilana Ramon; Bianchi Luis; Ramon Ayuso Juan; Pages Mario; Carrera Gemma; Cuatrecasas Miriam; Martin-Richard Marta; Cid Joan; Lozano Miguel; Castells Antoni; Garcia-Albeniz Xabier; Maurel Joan; Vilella Ramon;
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正文语种 eng
中图分类肿瘤学;
关键词
Cancer; Dendritic cells; Immunotherapy; Colorectal; Vaccine;

机译：癌症;树突状细胞;免疫治疗;结直肠癌;疫苗;

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1. Phase II randomised trial of autologous tumour lysate dendritic cell plus best supportive care compared with best supportive care in pre-treated advanced colorectal cancer patients [J] . Caballero-Banos Miguel, Benitez-Ribas Daniel, Tabera Jaime, European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2016,第Null期

机译：预治疗的晚期大肠癌患者自体肿瘤溶解产物树突状细胞加最佳支持治疗与最佳支持治疗的II期随机试验
2. Rationale and Design for the LUME-Colon 1 Study: A Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Nintedanib Plus Best Supportive Care Versus Placebo Plus Best Supportive Care in Patients With Advanced Colorectal Cancer Refractory to Standard Treatment [J] . Van Cutsem Eric, Yoshino Takayuki, Hocke Julia, Clinical colorectal cancer . 2016,第1期

机译：LUME-Colon 1研究的基本原理和设计：Nintedanib加最佳支持治疗的随机，双盲，安慰剂对照的III期临床试验与安慰剂加最佳支持治疗的难治性标准治疗大肠癌患者
3. Phase III trial of vinflunine plus best supportive care compared with best supportive care alone after a platinum-containing regimen in patients with advanced transitional cell carcinoma of the urothelial tract. [J] . Bellmunt J, Theodore C, Demkov T, Journal of Clinical Oncology . 2009,第27期

机译：在晚期尿路上皮移行细胞癌患者中，在接受含铂治疗后，与单独的最佳支持治疗相比，长春氟宁加最佳支持治疗的III期试验。
4. HIGH-RISK PATIENTS: SUPPORTIVE CARE, MONITORING, AND POSTOPERATIVE CARE [C] . Ralph Harvey Annual Meeting of the American Animal Hospital Association . 2011

机译：高风险患者：支持性护理，监测和术后护理
5. Supportive Care for Patients with Breast Cancer by Using an Interactive App During Neoadjuvant Chemotherapy: A Randomized Controlled Trial [D] . Fjell, Maria. 2021

机译：通过在Neoadjuvant化疗期间使用互动性应用的乳腺癌患者的支持性护理：随机对照试验
6. Complementary vaccination protocol with dendritic cells pulsed with autologous tumour lysate in patients with resected stage III or IV melanoma: protocol for a phase II randomised trial (ACDC Adjuvant Trial) [O] . Laura Ridolfi, Francesco de Rosa, Laura Fiammenghi, 1983

机译：切除III或IV期黑色素瘤患者的自体肿瘤溶解产物脉冲树突状细胞的补充疫苗接种方案：一项II期随机试验的方案（ACDC佐剂试验）
7. B2-03: Supportive care and chemotherapy (CT) versus supportive care alone in advanced non-small cell lung cancer (NSCLC): A meta-analysis using individual patient data (IPD) from randomised controlled trials (RCTs) [O] . Burdett Sarah, Johnson David, Stewart Lesley, 2007

机译：B2-03：晚期非小细胞肺癌（NSCLC）的支持治疗和化疗（CT）与单独支持治疗的比较：使用来自随机对照试验（RCT）的个体患者数据（IPD）进行的荟萃分析

Phase II randomised trial of autologous tumour lysate dendritic cell plus best supportive care compared with best supportive care in pre-treated advanced colorectal cancer patients

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