Modulation of the Coagulation Cascade Using Recombinant Factor Vila and Activated Protein C in a Severely Injured Trauma Patient

摘要

Exsanguination after trauma remains a leading cause of early death in severely injured patients [i]. Sepsis and multiple organ failure are significant causes of mortality in severely injured trauma patients who survive their injury and require a prolonged 1CLJ hospitalization [2]. Despite advances in operative technique and critical care medicine, the treatment options for patients with coagulopathic hemorrhage or severe sepsis have remained relatively unchanged. We report a unique case in which pharmacological modulators of coagulation, recombinant Factor Vila, and activated protein C were successfully used to treat massive hemorr-hage and then severe sepsis in a severely injured trauma patient.