Experimental study of the pharmacokinetics of a tryptophan-containing dipeptide GB-115.

Boyko SS; Kolyvanov GB; Zherdev VP; Gudasheva TA; Kiryanova EP; Seredenin SB

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Experimental study of the pharmacokinetics of a tryptophan-containing dipeptide GB-115.

机译：含色氨酸二肽GB-115药代动力学的实验研究。

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摘要

Pharmacokinetics of an original compound GB-115 (N-phenylhexanoylglycyltryptophan) synthesized on the basis of the structure of endogenous tetrapeptide cholecystokinin-4 was studied by means of high-performance liquid chromatography. Pharmacokinetic parameters were calculated after intravenous and peroral administration of GB-115. Our results indicate that this dipeptide is resistant to peptidases. The absolute bioavailability of GB-115 is 4.65%.

机译：通过高效液相色谱法研究了基于内源四肽胆囊收缩素-4结构合成的原始化合物GB-115（N-苯基己酰基糖基色氨酸）的药代动力学。静脉和经口给予GB-115后计算药代动力学参数。我们的结果表明该二肽对肽酶具有抗性。 GB-115的绝对生物利用度为4.65％。

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《Bulletin of experimental biology and medicine》 |2007年第3期|共2页
作者
Boyko SS; Kolyvanov GB; Zherdev VP; Gudasheva TA; Kiryanova EP; Seredenin SB;
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正文语种 eng
中图分类基础医学;
关键词
Pharmacokinetic; Dipeptides; Tryptophan; structure; Performance; 二肽类; 色氨酸;

机译：Pharmacokinetic;Dipeptides;Tryptophan;structure;Performance;二肽类;色氨酸;

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1. Experimental study of the pharmacokinetics of a tryptophan-containing dipeptide GB-115. [J] . Boyko SS, Kolyvanov GB, Zherdev VP, Bulletin of experimental biology and medicine . 2007,第3期

机译：含色氨酸二肽GB-115药代动力学的实验研究。
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4. Optimal Dynamic Discrimination in Tryptophan-Containing Dipeptides [C] . S. Afonina, O. Nenadl, A. Rondi, International Conference on Ultrafast Phenomena . 2013

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5. Ocular pharmacokinetics and efficacy of various amino acid and dipeptide prodrugs of ganciclovir. [D] . Gunda, Sriram. 2012

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7. Structural Studies of the Interaction between Indole Derivatives and Biologically Important Aromatic Compounds. Part XXIII. Sequence-Dependent Interaction of Acidic Amino Acid with Guanine Base in Tryptophan-Containing Dipeptides: Spectroscopic Studies. [O] . Hiromi IYO, Hitoshi UEDA, Yoshihide USAMI, 1991

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Experimental study of the pharmacokinetics of a tryptophan-containing dipeptide GB-115.

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