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Pharmacokinetics of Stereoisomeric Dipeptide Prodrugs of Acyclovir Following Intravenous and Oral Administrations in Rats: A Study Involving In vivo Corneal Uptake of Acyclovir Following Oral Dosing

机译：大鼠静脉和口服给药后阿昔洛韦立体异构体二肽前药的药代动力学：口服给药后涉及体内阿昔洛韦角膜摄取的研究

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摘要

ObjectiveTo delineate the plasma pharmacokinetics and determine the corneal uptake of valine based stereoisomeric dipeptide prodrugs of acyclovir (ACV) in rats.

机译：目的描述血浆药代动力学并确定缬氨酸基于阿昔洛韦（ACV）的缬氨酸立体异构二肽前药的角膜摄取。

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期刊名称 Ophthalmology and Eye Diseases
作者
Ravi S. Talluri; Ripal Gaudana; Sudharshan Hariharan; Ashim K. Mitra;
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作者单位

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年(卷),期 2009(1),-1
年度 2009
页码 21–31
总页数 11
原文格式 PDF
正文语种
中图分类眼科学;
关键词
acyclovir dipeptide prodrugs PEPT cornea;

机译：阿昔洛韦;二肽;前药;PEPT;角膜;

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专利

1. Pharmacokinetics of Stereoisomeric Dipeptide Prodrugs of Acyclovir Following Intravenous and Oral Administrations in Rats: A Study Involving In vivo Corneal Uptake of Acyclovir Following Oral Dosing [J] . Ravi S.Talluri, Ripal Gaudana, Sudharshan Hariharan, Ophthalmology and Eye Diseases . 2009,第1期

机译：大鼠静脉和口服给药后阿昔洛韦立体异构体二肽前药的药代动力学：口服给药后涉及体内阿昔洛韦角膜摄取的研究
2. Pharmacokinetics of acyclovir after intravenous infusion of acyclovir and after oral administration of acyclovir and its prodrug valacyclovir in healthy adult horses. [J] . Garre B, Shebany K, Gryspeerdt A, Antimicrobial agents and chemotherapy. . 2007,第12期

机译：静脉输注阿昔洛韦和口服阿昔洛韦及其前药伐昔洛韦在健康成年马中的阿昔洛韦药代动力学。
3. Disposition kinetics of a dipeptide ester prodrug of acyclovir and its metabolites following intravenous and oral administrations in rat [J] . Ravi S. Talluri Ripal Gaudana Sudharshan Hariharan Ritesh Jain and Ashim K. Mitra Clinical research and regulatory affairs. . 2009,第3期

机译：大鼠静脉内和口服给药后，阿昔洛韦及其代谢产物的二肽酯前药的处置动力学
4. Pharmacokinetics and Bioavailability of a Sulfadiazine/Trimethoprim Combination following Intravenous, Intramuscular, and Oral Administration in Ostriches (Struthio camelus) [C] . Tariq M. Hantash, Ehab A. Abu-Basha Annual Conference of the Association of Avian Veterinarians . 2008

机译：静脉注射，肌肉内和口服给药后磺胺嗪/三甲基氯化西瓜组合的药代动力学和生物利用度（Struthio Camelus）
5. Design of amino acid prodrugs of acyclovir for improved bioavailability and therapeutic activity: Utility in treating ocular, oral and genital herpes infections. [D] . Katragadda, Suresh. 2007

机译：设计用于提高生物利用度和治疗活性的阿昔洛韦的氨基酸前药：用于治疗眼，口腔和生殖器疱疹感染。
6. Pharmacokinetics of Acyclovir after Intravenous Infusion of Acyclovir and after Oral Administration of Acyclovir and Its Prodrug Valacyclovir in Healthy Adult Horses [O] . B. Garré, K. Shebany, A. Gryspeerdt, 2007

机译：静脉输注阿昔洛韦后以及口服阿昔洛韦及其前药伐昔洛韦在健康成年马中的阿昔洛韦药代动力学
7. Pharmacokinetics of Stereoisomeric Dipeptide Prodrugs of Acyclovir following Intravenous and Oral Administrations in Rats: A study Involving in vivo corneal Uptake of Acyclovir following Oral Dosing [O] . Ravi S. Talluri, Ripal Gaudana, Sudharshan Hariharan, 2009

机译：阿昔洛韦立体异构体二肽前药在大鼠静脉和口服给药后的药代动力学：口服给药后体内角膜摄入阿昔洛韦的研究
8. Effect of Repeated Oral Doses of Ethiprole on the Biliary Excretion and Pharmacokinetics of Intravenously Administered 1251-Thyroxine (T4) in Male Rats [R] . 2008

机译：口服重复口服乙醚对雄性大鼠静脉注射1251-甲状腺素（T4）胆汁排泄和药代动力学的影响

Pharmacokinetics of Stereoisomeric Dipeptide Prodrugs of Acyclovir Following Intravenous and Oral Administrations in Rats: A Study Involving In vivo Corneal Uptake of Acyclovir Following Oral Dosing

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