Multiple cutaneous and uterine leiomyomatosis in a 36-year-old female, and discussion of hereditary leiomyomatosis and renal cell carcinoma

摘要

Hereditary leiomyomatosis and renal cell carcinoma (HLRCC), also known as Reed's syndrome, is a rare but important syndrome that should be recognized, and those families affected by it should be counseled, as it is secondary to a genetic mutation that will affect future generations. A 36-year-old Caucasian female presented to the Dermatology Department of the Naval Medical Center San Diego in June 2009. One year prior to presentation, the patient had a sudden eruption of at least twenty superficial pink-brown papules extending across her back, shoulders, and upper arms which were mildly tender when rubbed (see Figs. 1 and 2). A review of systems was non-contributory, and her past medical history was negative for skin cancers. The patient's past surgical history revealed that she had undergone a hysterectomy at age 28 years for multiple leiomyomas. A thorough review of her family history was significant for her mother's having undergone a hysterectomy at age 21 years and having been diagnosed with metastatic renal cell carcinoma at age 42 years. The patient's brother, her only sibling, has no skin manifestations or history of kidney disease. She has a healthy 7-year-old daughter.