Impact of diabetes mellitus on plaque vulnerability and clinical outcome in patients with acute myocardial infarction with plaque rupture

摘要

The high event rate in diabetic acute myocardial infarction (AMI) patients may be associated with abnormalities in endothelial function and vascular smooth muscle cell function which contribute to atherosclerosis and its complications [1-3] and unstable plaque characteristics [more plaques, more plaque rupture (PR), more thrombus, and more necrotic core], and increased inflammatory status compared with non-diabetic AMI patients [4]. We evaluated the impact of diabetes mellitus on intravascular ultrasound (IVUS) findings and acute complications including no-reflow and acute stent thrombosis, and 12-month clinical outcome after stent implantation in AMI patients with PR.