Analysis of p15INK4b and p16INK4a gene methylation in patients with oral squamous cell carcinoma.

摘要

Cancer is the third leading cause of death in Iran, after coronary heart disease and accidents (Mousavi and Somi 2009). Apart from alterations in the various cellular oncogenes, dysregulation of tumor suppressor genes is an important event in the pathogenesis of cancer. Tumor suppressor genes, especially those involved in cell cycle regulation, are inactivated frequently in a variety of cancers (Cunningham and Roussel 2001).