Gene-based pathway enrichment analysis of oral squamous cell carcinoma patients

摘要

Oral Cancer has been characterized as a complex disease and involves dynamic genomic changes. These changes reveal the ability to explore the interactions of the molecules and of differentially expressed genes that are involved in cancer progression. Moreover, based on this knowledge the identification of differentially expressed genes and pathways is of great importance. The last decade pathway analysis has become a first choice in order to study the underlying biology of differentially expressed genes associated with a disease. In the present study we exploit genes that have been characterized as oral cancer risk associated in order to further perform pathway enrichment analysis. According to our results we found significant pathways in which the disease associated genes have been identified as strongly enriched.