A NOVEL TWO PHASE RETRIEVAL MECHANISM FOR A CLINICAL CASE BASED REASONING SYSTEM FOR RADIOTHERAPY TREATMENT PLANNING

摘要

This paper presents a decision support system for radiotherapy treatment planning for head, neck and brain cancer. The aim of a treatment plan is to apply radiation to kill tumor cells, while minimizing the damage to healthy tissue and critical organs. Since treatment planning is a complex decision making process that relies heavily on the subjective experience of clinicians, we propose the use of case-based reasoning (CBR), in which problems are solved based on the solutions of similar past problems. This paper focuses on the case retrieval process of a CBR system. The attributes, which describe the cases, are selected by assessing their effect on the performance of the CBR system. We have developed a context sensitive local weighting scheme that assigns weights to attributes based on their value and the values of other attributes in the target case. A novel two phase retrieval mechanism is developed, in which each phase is optimized to retrieve a particular part of the solution. We also present an original use of fuzzy logic in order to represent nonlinearity in the similarity measure. Experiments, which evaluate the similarity measure using real brain cancer patient cases, show promising results.