Guidelines on the diagnosis, investigation and management of chronic lymphocytic leukaemia

摘要

The guideline group was selected to be representative of UK based medical experts and patients representatives. Recommendations are based on a review of the literature using Med-line/Pubmed searches under the heading, chronic lymphocytic leukaemia, up to August 2011, and data presented at the American Society of Haematology in 2011. The writing group produced the draft guideline, which was subsequently revised by consensus by members of the Haemato-oncology Task Force of the British Committee for Standards in Haematology (BCSH). The guideline was then reviewed by a sounding board of approximately 50 UK haematologists, the British Committee for Standards in Haematology (BCSH) and the British Society for Haematology Committee and comments incorporated where appropriate. The 'GRADE' system was used to quote levels and grades of evidence, details of which are available in the BCSH guideline pack http://www.bcshguidelines. com/BCSH_PROCESS/42_EVIDENCE_LEVELS_AND_GRAD ES_OF_RECOMMENDATION.html. The objective of this guideline is to provide healthcare professionals with clear guidance on the management of patients with chronic lymphocytic leukaemia. In all cases individual patient circumstances may dictate an alternative approach.