HETEROCYCLIC SYSTEMS CONTAINING BRIDGEHEAD NITROGEN ATOM:FACILE SYNTHESIS AND BIOLOGICAL ACTIVITY OF SPIRO [CYCLOHEPTANE-1,7'(8'H)-[6H] PYRAZOLO [3',4':4,5] THIAZOLO [3,2-b] -s-TETRAZINES]

摘要

A facile synthesis of 3',3'a-dihydro-2',3'-diarylspiro [cycloheptane-1,7'(8'H)-[6H] pyrazolo [3',4':4,5] thiazolo [3,2-b]-s-tetrazines] 4 has been achieved by the condensation of 1',2',4',5'-tetraazaspiro [5,6] cycloheptane-3'-thione 1 with chloroacetic acid and then with aldehydes to yield 7'-arylidene-6'(7'H)-oxospiro [cycloheptane-1,3' (4'H)-(2H) thiazolo [3,2-b]-s-tetrazines] 3 followed by treatment with 2,4-dinitrophenyl hydrazine.The antibacterial and antifungal activity of some of the compounds have also been evaluated.