SYNTHESIS OF BIOLOGICALLY ACTIVE COMPOUNDS CONTAINING QUINOLINONE- QUINAZOLINONE MOIETY

摘要

The 7-hydroxy-4-methylquinolin-2-(1 H)-one 1 on treatment with phthalic anhydride produced 2-[{(4"-methyl-2'-oxo-1 ',2'-dihydroquinolin-7'-yl)-oxy}-carbonyl]-benzoic acid 2. The compound 2 on treatment with 8-amino-4-phenylquinazolin-2-(1 H)-one 3 produced 4-methyl-2-oxo-1,2-dihydroquinolin-7-yl-2'-[{(4"-phenyl-3",4"-dihydroquinazolin-2"-(1"H)-one-8"-yl)-amino}-carbonyl]-benzoate 4. Further treatment of compound 1 with 4-oxo-2-phenylquinazolin-3-(4H)-carboxamide 5 synthesized 4-methyl-2-oxo-1,2-dihydroquinclin-7-yl-2'-[{(2"-phenylquinazolin-4''-(3"H)-one-3"-yl)-carbonyl-amino-carbonyl}]-benzoate 6. On treatment with 4-(4'-oxo-2'-phenylquinazolin-3'(4'W)-yl) benzenesulfonamide7, compound 1 yielded 4-methyl-2-oxo-1,2-dihydroquinolin-7-yl-2'-[{(N-4"-(2"-phenyl-4"'-oxoquinazolin-3'"-(4"'-H)-yl)-phenyl}-sulfonyl]-amino-carbonyl-benzoate 8. Compound talso yielded 4-methyl-2-oxo-1,2-dihydroquinolin-7-yl-2'-[{(4"-oxo-2"-phenyl-quinazolin-3"(4"H)-yl)-amino}-carbonyl]-benzoate 10 on treatment with 3-amino-2-phenylquinazolin-4(3H)-one 9. All these synthesized compounds were confirmed by physical and spectal data and they were screened for antimicrobial, anxiolytic and anthelmintic activity.