BIOLOGICALLY ACTIVE COMPOUND CONTAINING CODING OLIGONUCLEOTIDE (VERSIONS), METHOD FOR SYNTHESIS THEREOF, LIBRARY OF COMPOUNDS (VERSIONS), METHOD FOR SYNTHESIS THEREOF, AND METHOD OF SEARCHING FOR COMPOUND BOUND WITH BIOLOGICAL TARGET (VERSIONS)

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to biological chemistry and can be used to determine compounds bound with a biological target. A compound which contains a functional component and a coding oligonucleotide is synthesised. The synthesis method involves binding an additional structure fragment to the starting functional component and enzyme doping of the starting oligonucleotide with an additional oligonucleotide. The oligonucleotide is double-stranded, is bound with the functional component by each of its chains and defines its structure. This synthesis method is employed in the method of producing a library of compounds, wherein the structure of the functional component is defined by the coding oligonucleotide. The library of compounds is used in the method of searching for compounds bound with a biological target.;EFFECT: invention widens the range of chemical reactions used to build molecules in the presence of a chemically non-modified oligonucleotide label, with high accuracy of introducing oligonucleotide labels into chemical structures and obtain libraries containing multiple copies of each member.;118 cl, 14 dwg, 7 tbl, 10 ex