BIOLOGICALLY ACTIVE COMPOUND CONTAINING AN ENCODING OLIGONUCLEOTIDE (OPTIONS), METHOD OF ITS SYNTHESIS, LIBRARY OF COMPOUNDS (OPTIONS), METHOD OF ITS SYNTHESIS AND SIMILAR RESPONSIBILITY

摘要

1. A method of synthesizing a compound containing a functional component that is effectively linked to a coding oligonucleotide, characterized in that an initiator compound consisting of an initial functional component containing n structural fragments is used as the starting compound, where n is an integer of 1 or more, at least one reactive group, and effectively linked to the original oligonucleotide; reacting said initiator compound with a structural fragment containing at least one reactive group complementary to the reactive group of the initiator compound under conditions suitable for the formation of a covalent bond between the reactive groups; carry out the interaction of the original oligonucleotide with a new introduced oligonucleotide, which defines a structural fragment covalently linked to the initiator compound, and the interaction of the original oligonucleotide with the new oligonucleotide is carried out in the presence of an enzyme that catalyzes the ligation of the original oligonucleotide and the new oligonucleotide under suitable conditions to form a coding oligonucleotide; and the result is a compound containing a functional component containing n + 1 structural fragments and effectively linked to the coding oligonucleotide. 2. The method according to claim 1, characterized in that the functional component of the obtained compound contains at least one reactive group, and said compound is used as an initiator compound to carry out a repeated cycle of all steps