Wolff rearrangement of N~(alpha)- Boc-/Z-protected aminodiazoketones to the corresponding beta-amino acids under microwave irradiation

摘要

The Wolff rearrangement of N~alpha-Boc-/Z-protected aminodiazoketones in the presence of silver benzoate under microwave irradiation is described.The reaction is found to be rapid,efficient and complete.It results in the isolation of Boc-/Z- protected-beta-amino acids in good purity as well as yield.