Synthesis of alpha-amino-alpha',alpha'-dihaloketones and process for the preparation of beta-amino acid derivatives by the use of the same

摘要

The present invention provides a commercially profitable process for producing a beta -amino acid ester derivative which comprises reacting an alpha -amino acid ester derivative with a base and a dihalomethane, reacting the same with a lithium amide and an alkyllithium in succession, and treating the reaction product with an acid in an alcohol.