Process for Synthesis of alpha , omega -Alkanediphosphonic Acids (Triphenyl Phosphite; Trischloroalkyl Phosphite)

摘要

Process for synthesis of alpha , omega -alkanediphosphonic acids is characterized by the fact that triphenyl phosphite and trischloroalkyl phosphite in a mole ratio of 2:1 are heated to temperatures of 210 to 300 exp 0 C, preferably 220 to 280 exp 0 C, and the resulting ester is converted to the free acid by saponification with aqueous sodium hydroxide and subsequent passage of gaseous hydrogen chloride. (ERA citation 08:041791)