Network-selective vulnerability of the human cerebellum to Alzheimer's disease and frontotemporal dementia

摘要

Atrophy patterns in neurodegenerative diseases reflect disruptions of intrinsic connectivity networks in the cerebral cortex. Guo et al. show that circumscribed and distinct atrophy is also present in the cerebellum, following the topographic organization of intrinsic cerebro-cerebellar connectivity. Network-based degeneration may be a universal framework underlying pathogenesis in the ageing brain.See Schmahmann (doi:10.1093/brain/aww064) for a scientific commentary on this article.