首页> 中文期刊> 《世界核心医学期刊文摘:神经病学分册》 >大部分海马硬化性痴呆患者可表现为额颞性痴呆

大部分海马硬化性痴呆患者可表现为额颞性痴呆

             

摘要

cqvip:Hippocampal sclerosis dementia (HSD) is a disease of unknown etiology and pathogenesis. To determine whether HSD cases could be reclassified as variants of frontotemporal dementia (FTD), a heterogeneous group of disorders, 18 brain autopsy cases previously diagnosed as HSD were re evaluated. In 11 cases, ubiquitinated neuronal inclusions, similar to those of motor neuron disease inclusion dementia (MNDID), were found. Brain levels of soluble and insoluble tau were normal. Most patients with pathologic findings of HSD may actually have the MNDID variant of FTD.

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