Synthesis, characterization and antibacterial activity of some schiff bases of 2-amino-3-(N-tolyl carboxamido)-4,5-trimethelene thiophenes

摘要

2-Amino-3-(N-tolyl carboxamido)-4,5-trimethelene thiophenes (1-III) were synthesized by Gewald reaction. Later, the compounds I-III were treated with ten different substituted aryl aldehydes to yield thirty new Schiff bases (Ia-j to IIIa-j). The compounds were characterized by spectral data and were screened for antibacterial activity. Some of these Schiff bases exhibited promising activity.