Synthesis, Characterization and Antibacterial Activity of Some Schiff Bases of 2-Amino-3-(N-Tolyl Carboxamido)-4,5,6,7-Tetrahydro Benzo (b) Thiophenes

摘要

2-Amino-3-(N-tolyl carboxamido)-4,5,6,7-tetrahydro benzo (b) thiophenes (I-III) were synthesized by Gewald reaction. Later, the compounds I-III were treated with ten different substituted arylaldehydes to yield thirty new Schiff bases (I a-j to III a-j). The compounds were characterized by spectral data and were screened for antibacterial activity. Some of these Schiff bases exhibited promising activity.