Synthesis and in vitro cytotoxicity of- 1,3-dioxoindan-2-carboxylic acid arylamides.

Jung JK; Ryu J; Yang SI; Cho J; Lee H

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Synthesis and in vitro cytotoxicity of- 1,3-dioxoindan-2-carboxylic acid arylamides.

机译：-1，3-二氧杂茚满-2-羧酸芳基酰胺的合成和体外细胞毒性。

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A series of 1,3-dioxoindan-2-carboxylic acid arylamides were synthesized and evaluated for in vitro cytotoxicity against four human cancer cell lines (HOP62, SK-OV-3, MD-MB-468 and T-47D). The most active was compound 3e (1.2 microM against SK-OV-3 cell line) bearing a 4-methyl substituent.

机译：合成了一系列的1,3-二氧杂茚满-2-羧酸芳基酰胺，并评估了其对四种人类癌细胞系（HOP62，SK-OV-3，MD-MB-468和T-47D）的体外细胞毒性。活性最高的是带有4-甲基取代基的化合物3e（对SK-OV-3细胞系而言为1.2 microM）。

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《Archives of pharmacal research》 |2004年第10期|共4页
作者
Jung JK; Ryu J; Yang SI; Cho J; Lee H;
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正文语种 eng
中图分类药学;
关键词
Cytotoxicity; In Vitro; Carboxylic Acids; Synthesis; 羧酸类;

机译：Cytotoxicity;In Vitro;Carboxylic Acids;Synthesis;羧酸类;

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1. Synthesis and in vitro cytotoxicity of- 1,3-dioxoindan-2-carboxylic acid arylamides. [J] . Jung JK, Ryu J, Yang SI, Archives of pharmacal research . 2004,第10期

机译：-1，3-二氧杂茚满-2-羧酸芳基酰胺的合成和体外细胞毒性。
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Synthesis and in vitro cytotoxicity of- 1,3-dioxoindan-2-carboxylic acid arylamides.

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