Convenient Preparation of Chiral alpha,beta-Epoxy Ketones via Claisen-Schmidt Condensation-Epoxidation Sequence

摘要

A novel Clasisen-Schmidt condensation-epoxidation sequence of aldehydes and ketones was developed to produce a series of chiral alpha,beta-epoxy ketones under asymmetric phase-transfer catalytic conditions.The organocatalytic method reported here can afford chiral alpha,beta-epoxy ketones under mild conditions with moderate to good yields and up to 96% ee.