催化非脱羧克莱森缩合反应的新型酮酶

摘要

Ketosynthases are essential for several metabolic pathways and play a vital function in biosynthesis of carbon-carbon bond.Until now, decarboxylative Claisen reaction has been intensitively studied, while the research of ketosynthases which catalyzed the non-decarboxylative Claisen condensations is relatively scarce.Recently ,some new progresses have been made in this field.In this paper, novel ketosynthases have been discussed including their enzymatic characteristics, structure basis, catalytic mechanism and application prospect.%酮酶对于多种生物代谢途径至关重要,且对碳碳键的生物合成起关键作用.目前,对脱羧的克莱森缩合反应研究较为深入,而催化非脱羧克莱森缩合反应的酮酶的研究工作相对较少.最近,在这方面的研究取得了一些新的进展.本文论述了与之相关的新型酮酶的酶学特性、结构基础、催化机制以及应用前景.