METHOD FOR PRODUCING CHIRAL ALPHA,BETA-EPOXY KETONES

摘要

A process is claimed for the enantioselective epoxidation of α,β-unsaturated ketones, in which a compound of the general formula I,; ;is reacted with an oxidizing agent to form α,β-epoxy ketones of the general formula II,; ;in which R¹, R², R³ are as defined above. The α,β-epoxy ketones of the general formula II can be obtained in good yields and outstanding enantioselectivities from α,β-unsaturated ketones of the general formula I by epoxidation with hydrogen peroxide in the presence of a chiral catalyst, such as amino compounds and their acid addition salts.