Deoxycholic Acid-Derived Biaryl Phosphites as Versatile and Enantioselective Ligands in the Rhodium-Catalyzed Conjugate Addition of Arylboronic Acids to Nitroalkenes

摘要

A highly enantioselective conjugate addition of arylboronic acids to cyclic as well as acyclic aromatic and aliphatic nitroalkenes is presented. The rhodium complexes obtained from deoxycholic acid-derived binaphthyl and flexible biphenyl phosphites showed good activity as well as very high enantiose-lectivity (ee up to 99%) in the conjugated addition even in the presence of challenging substrates such as 1-nitrocyclohexene or aliphatic acyclic nitroalkenes.