Metal-Catalyzed Copolymerization of Imines and CO:A Non-Amino Acid Route to Polypeptides

摘要

Polypeptides are an exceptionally significant class of biopo-lymers that not only are responsible for both the structure and function of most living things but also have broad applications in materials,catalysis,and pharmaceuticals.For a century,almost all studies on polypeptide synthesis have been based on the use of amino acids as starting materials,which requires tedious procedures for presynthesis of amino acids and subsequent activation of the highly stable carboxyl groups using stoichiometric amounts of special reagents to form peptide bonds.