NON-AMINO ACID METHOD FOR CHEMICAL TOTAL SYNTHESIS OF POLYPEPTIDES

摘要

Provided is a non-amino acid method for chemical total synthesis of polypeptides. Said non-amino acid method for chemical total synthesis of polypeptides uses as a raw material ketoamide compounds, which are synthesized into a polypeptide by means of reductive amination under acetal protection. The present non-amino acid method for chemical synthesis of polypeptides has the advantages of high synthesis efficiency, low cost, broad applicability, few side reactions, and ease of popularization.