Synthesis of Chiral 1,1'-Iminodicarboxylic Acid Derivatives from a-Amino Acids, Aldehydes, Isocyanides, and Alcohols by the Diastereoselective Five-Center-Four-Component Reaction

摘要

Chemical compounds are usually synthesized in several reaction steps. The intermediates must be separated and purified before they are used as starting materials in the next reaction. The total yield of such an iterative synthesis decreas.es sharply with the number of steps. Many compounds can also be prepared much faster and with higher yields by one-pot multicom-ponent reactions (MCR). The scope of the four-component reaction (U-4CR) was only recognized in 1958, shortly after isocyanides had becomeeasily accessible.