Interpretation of p16(INK4a)/Ki-67 Dual Immunostaining for the Triage of Human Papillomavirus-Positive Women by Experts and Nonexperts in Cervical Cytology

摘要

BACKGROUNDThe triage of human papillomavirus (HPV)-positive women is needed to avoid overreferral to colposcopy. p16(INK4a) immunostaining is an efficient triage method. p16(INK4a)/Ki-67 dual staining was introduced mainly to increase reproducibility and specificity compared with stand-alone p16(INK4a) staining.