Nilotinib Deregulates Cell Cycle Checkpoints, ABC Transporters Genes and JAK-STAT Signaling Pathway of CD34+/Lin- Cells in Chronic-Phase Chronic Myeloid Leukemia (CP-CML) Patients after 12 Months of Treatment

Trojani Alessandra; Pungolino Ester; Rossi Giuseppe; Dadda Mariella; Lodola Milena; Dal Molin Alessandra; Baruzzo Giacomo; Perego Alessandra; Turrini Mauro; Elena Chiara; Borin Lorenza Maria; Iurlo Alessandra; Malato Simona; Spina Francesco; Latargia Maria Luisa; Spedini Pierangelo; Artale Salvatore; Anghilieri Michela; Cristina Carraro Maria; Bucelli Cristina; De Canal Gabriella; Morra Enrica; Cairoli Roberto

首页> 外文期刊>Blood: The Journal of the American Society of Hematology >Nilotinib Deregulates Cell Cycle Checkpoints, ABC Transporters Genes and JAK-STAT Signaling Pathway of CD34+/Lin- Cells in Chronic-Phase Chronic Myeloid Leukemia (CP-CML) Patients after 12 Months of Treatment

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Nilotinib Deregulates Cell Cycle Checkpoints, ABC Transporters Genes and JAK-STAT Signaling Pathway of CD34+/Lin- Cells in Chronic-Phase Chronic Myeloid Leukemia (CP-CML) Patients after 12 Months of Treatment

机译：NiLotinib Dereculates细胞周期检查点，ABC转运蛋白基因和JAK-STAT在慢性相慢性骨髓白血病（CP-CML）患者中的CD34 + / LIN细胞的途径在12个月后治疗后

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来源
《Blood: The Journal of the American Society of Hematology》 |2018年第novaelatreatmentappr期|共4页
作者
Trojani Alessandra; Pungolino Ester; Rossi Giuseppe; Dadda Mariella; Lodola Milena; Dal Molin Alessandra; Baruzzo Giacomo; Perego Alessandra; Turrini Mauro; Elena Chiara; Borin Lorenza Maria; Iurlo Alessandra; Malato Simona; Spina Francesco; Latargia Maria Luisa; Spedini Pierangelo; Artale Salvatore; Anghilieri Michela; Cristina Carraro Maria; Bucelli Cristina; De Canal Gabriella; Morra Enrica; Cairoli Roberto;
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作者单位

ASST Grande Osped Metropolitano Niguarda Dept Hematol Milan Italy;

ASST Grande Osped Metropolitano Niguarda Dept Hematol Milan Italy;

ASST Spedali Civili Brescia Dept Hematol Brescia Italy;

ASST Spedali Civili Brescia Dept Hematol Brescia Italy;

ASST Grande Osped Metropolitano Niguarda Dept Hematol Milan Italy;

Univ Padua Dept Informat Engn Padua Italy;

Univ Padua Dept Informat Engn Padua Italy;

Desio Hosp Internal Med Hematol Desio Italy;

Valduce Hosp Dep Internal Med Como Italy;

Fdn IRCCS Policlin San Matteo Dept Hematol Oncol Pavia Italy;

San Gerardo Hosp Dept Hematol Monza Italy;

Fdn IRCCS Ca Granda Osped Maggiore Policlin Hematol Div Milan Italy;

Hematol &

Bone Marrow Transplantat Unit San Raffaele Sci Unit Milan Italy;

Fdn IRCCS Ist Tumori Div Hematol Milan Italy;

ASST Valle Olona Osped Circolo Busto Arsizio Italy;

ASST Cremona Cremona Italy;

ASST Valle Olona St Antonio Abate Gallarate Italy;

ASST Lecco Lecce Italy;

Sacco Hosp Hematol &

Transfus Med Milan Italy;

Fdn IRCCS Ca Granda Osped Maggiore Policlin Hematol Div Milan Italy;

ASST Grande Osped Metropolitano Niguarda Pathol Dept Cytogenet Milan Italy;

ASST Grande Osped Metropolitano Niguarda Lombardy Hematol Network Milan Italy;

ASST Grande Osped Metropolitano Niguarda Dept Hematol Milan Italy;

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原文格式 PDF
正文语种 eng
中图分类血液及淋巴系疾病;
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专利

1. Nilotinib Deregulates Cell Cycle Checkpoints, ABC Transporters Genes and JAK-STAT Signaling Pathway of CD34+/Lin- Cells in Chronic-Phase Chronic Myeloid Leukemia (CP-CML) Patients after 12 Months of Treatment [J] . Trojani Alessandra, Pungolino Ester, Rossi Giuseppe, Blood: The Journal of the American Society of Hematology . 2018,第NovaelaTreatmentAppr期

机译：NiLotinib Dereculates细胞周期检查点，ABC转运蛋白基因和JAK-STAT在慢性相慢性骨髓白血病（CP-CML）患者中的CD34 + / LIN细胞的途径在12个月后治疗后
2. Tyrosine Kinase Inhibitor (TKI) Switching Patterns during the First 12 Months in Simplicity, an Observational Study of Chronic-Phase Chronic Myeloid Leukemia (CP-CML) Patients (Pts) in Routine Clinical Practice [J] . Goldberg Stuart, Michallet Mauricette, Hehlmann Rudiger, Blood: The Journal of the American Society of Hematology . 2016,第22期

机译：酪氨酸激酶抑制剂（TKI）在常规临床实践中，在前12个月内为前12个月内切换模式，慢性相慢性骨髓白血病（CP-CML）患者（CP-CML）患者（PTS）的观察研究
3. Expression differences of genes in the PI3K/AKT, WNT/b-catenin, SHH, NOTCH and MAPK signaling pathways in CD34+ hematopoietic cells obtained from chronic phase patients with chronic myeloid leukemia and from healthy controls [J] . R. de Cássia Viu Carrara, A. M. Fontes, K. J. Abraham, Clinical & translational oncology : . 2018,第4期

机译：CD34 +造血细胞中PI3K / AKT，WNT / B-Catenin，SHH，NOTCH和MAPK信号通路中基因的表达差异，从慢性骨髓白血病和健康对照中获得慢性相位患者
4. Culture, characterization, and cytotoxic activity of gammadelta T cells from patients with Ph(+) chronic myeloid leukemia: A potential role in cell therapy. [D] . Malas Al-Beirouti, Bassim Tahseen. 2002

机译：来自Ph（+）慢性髓细胞性白血病患者的γδT细胞的培养，鉴定和细胞毒性活性：在细胞治疗中的潜在作用。
5. Nilotinib interferes with cell cycle, ABC transporters and JAK-STAT signaling pathway in CD34+/lin- cells of patients with chronic phase chronic myeloid leukemia after 12 months of treatment [O] . Alessandra Trojani, Ester Pungolino, Alessandra Dal Molin, 2012

机译：尼洛替尼治疗12个月后慢性期慢性髓细胞性白血病患者CD34 + / lin-细胞中干扰细胞周期，ABC转运蛋白和JAK-STAT信号通路
6. Nilotinib interferes with cell cycle, ABC transporters and JAK-STAT signaling pathway in CD34+/lin- cells of patients with chronic phase chronic myeloid leukemia after 12 months of treatment [O] . Alessandra Trojani, Ester Pungolino, Alessandra Dal Molin, 2019

机译：Nilotinib在慢性相位慢性骨髓白血病患者的CD34 + / Lin细胞中干扰细胞周期，ABC转运蛋白和JAK-STAT信号通路在12个月后治疗后

Nilotinib Deregulates Cell Cycle Checkpoints, ABC Transporters Genes and JAK-STAT Signaling Pathway of CD34+/Lin- Cells in Chronic-Phase Chronic Myeloid Leukemia (CP-CML) Patients after 12 Months of Treatment

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